Pharmacogenomics Of Membrane Transporters Focus On The Organic Cation Transporter Oct1

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Pharmacogenomics Of Membrane Transporters Focus On The Organic Cation Transporter Oct1

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Author : Yan Shu
language : en
Publisher:
Release Date : 2006

Pharmacogenomics Of Membrane Transporters Focus On The Organic Cation Transporter Oct1 written by Yan Shu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.

In the final part of this dissertation, the role of OCT1 in hepatic triglyceride homeostasis was explored. A series of assays and measurements were performed in obese (ob/ob) and lean (OB/OB) mice in the presence or absence of the Oct1 allele. The data suggest that in addition to its function as a drug transporter, OCT1 is involved in nutrient, particularly triglyceride and glucose, homeostasis and may be important in the development of fatty liver.

Dissertation Abstracts International

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Author :
language : en
Publisher:
Release Date : 2007

Dissertation Abstracts International written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Dissertations, Academic categories.

Organic Cation Transporters

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Author : Giuliano Ciarimboli
language : en
Publisher: Springer
Release Date : 2015-12-17

Organic Cation Transporters written by Giuliano Ciarimboli and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-17 with Medical categories.

This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues. This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.

Physiology Biochemistry And Pharmacology Of Transporters For Organic Cations

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Author : Giuliano Ciarimboli
language : en
Publisher: MDPI
Release Date : 2021-06-24

Physiology Biochemistry And Pharmacology Of Transporters For Organic Cations written by Giuliano Ciarimboli and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-24 with Medical categories.

Membrane transporters are of vital importance for cells. They mediate the flux of many substances through the plasma membrane. In this book, the transporters for organic cations, a special class of membrane transporters, are presented. Transporters belonging to this class are important because they allow many neurotransmitters (e.g., histamine and serotonin) and many drugs (e.g., trospium and tofacitinib) to permeate the plasma membrane. Therefore, transporters for organic cations can modulate the action of neurotransmitters and drugs, having in this way important physiological and pharmacological implications. These aspects are illustrated in original works and reviews presented in this book. Using a system biology approach, the global significance of different transporters working together has been illustrated. Regulation mechanisms determining their expression in specific organs and modulating their function are also described in this book, also concerning their role for special drug toxicities. Such an aspect is also discussed in relationship to mutations (single nucleotide polymorphisms) of transporters for organic cations. Finally, the translational value of studies performed in flies, mice, and rats is discussed. Therefore, this book offers integrative information on transporters for organic cations, which may be of interest to beginners and specialized scientists in this field.

The Role Of Membrane Transporters In The Pharmacokinetics Of Psychotropic Drugs In Vitro Studies With Special Focus On Organic Cation Transporters

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Author :
language : en
Publisher:
Release Date : 2015

The Role Of Membrane Transporters In The Pharmacokinetics Of Psychotropic Drugs In Vitro Studies With Special Focus On Organic Cation Transporters written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.

The treatment of common psychiatric disorders like major depression, schizophrenia and bipolar disorder is characterized by low efficacy and variability in the case of depression and bipolar disorder, and of undesirable side effects in the case of schizophrenia. One of the explanations is that the drug may not be reaching its site of action, at concentrations that are high enough to provoke a response. On the other hand, poor elimination of the drug from the body may lead to high plasma concentrations, which may cause undesirable side effects. Variations in membrane transport at the blood-b...

Membrane Transporters In Drug Discovery And Development

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Author : Qing Yan
language : en
Publisher: Humana
Release Date : 2016-08-23

Membrane Transporters In Drug Discovery And Development written by Qing Yan and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-23 with Medical categories.

Studies of membrane transporters have had a great impact on our understanding of human diseases and the design of effective drugs. In Membrane Transporters in Drug Discovery and Development: Methods and Protocols, expert researchers provide practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development. Chapters include new and useful fields and methodologies, including pharmacogenomics, nutrigenomics, systems biology, bioinformatics, nuclear magnetic resonance (NMR), imaging, and quantitative real-time-PCR. Transporter studies in drug discovery and development for various diseases are discussed, including neuropsychiatric disorders, cardiovascular diseases, ophthalmic diseases, cancer, and diabetes. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Wide-ranging and current, Membrane Transporters in Drug Discovery and Development: Methods and Protocols delivers a collection of practical protocols that can be used immediately in the lab, along with critical surveys of key topics by leading researchers in the field.

Pharmacogenomics Of Human Drug Transporters

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Author : Toshihisa Ishikawa
language : en
Publisher: Wiley
Release Date : 2013-04-15

Pharmacogenomics Of Human Drug Transporters written by Toshihisa Ishikawa and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-15 with Medical categories.

Sets the foundation for safer, more effective drug therapies With this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and development efforts. In particular, the book explains how new findings in the field now enable researchers to more accurately predict drug interactions and adverse drug reactions. Moreover, it sets the foundation for the development of drug therapies that are tailored to an individual patient's genetics. Pharmacogenomics of Human Drug Transporters serves as a comprehensive guide to how transporters regulate the absorption, distribution, and elimination of drugs in the body as well as how an individual's genome affects those processes. The book's eighteen chapters have been authored by a team of leading pioneers in the field. Based on their own laboratory and clinical experience as well as a thorough review of the literature, these authors explore all facets of drug transporter pharmacogenomics, including: Individual drug transporters and transporter families and their clinical significance Principles of altered drug transport in drug–drug interactions, pharmacotherapy, and personalized medicine Emerging new technologies for rapid detection of genetic polymorphisms Clinical aspects of genetic polymorphisms in major drug transporter genes Future research directions of drug transporter pharmacogenomics and the prospect of individualized medicine Pharmacogenomics of Human Drug Transporters opens the door to new drug discovery and development breakthroughs leading to safer and more effective customized drug therapies.The book is recommended for pharmaceutical scientists, biochemists, pharmacologists, clinicians, and genetics and genomics researchers.

Physiology Biochemistry And Pharmacology Of Transporters For Organic Cations

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Author : Giuliano Ciarimboli
language : en
Publisher:
Release Date : 2021

Physiology Biochemistry And Pharmacology Of Transporters For Organic Cations written by Giuliano Ciarimboli and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.

Membrane transporters are of vital importance for cells. They mediate the flux of many substances through the plasma membrane. In this book, the transporters for organic cations, a special class of membrane transporters, are presented. Transporters belonging to this class are important because they allow many neurotransmitters (e.g., histamine and serotonin) and many drugs (e.g., trospium and tofacitinib) to permeate the plasma membrane. Therefore, transporters for organic cations can modulate the action of neurotransmitters and drugs, having in this way important physiological and pharmacological implications. These aspects are illustrated in original works and reviews presented in this book. Using a system biology approach, the global significance of different transporters working together has been illustrated. Regulation mechanisms determining their expression in specific organs and modulating their function are also described in this book, also concerning their role for special drug toxicities. Such an aspect is also discussed in relationship to mutations (single nucleotide polymorphisms) of transporters for organic cations. Finally, the translational value of studies performed in flies, mice, and rats is discussed. Therefore, this book offers integrative information on transporters for organic cations, which may be of interest to beginners and specialized scientists in this field.

Drug Transporters

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Author : Guofeng You
language : en
Publisher: John Wiley & Sons
Release Date : 2007-08-13

Drug Transporters written by Guofeng You and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-13 with Science categories.

A comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body The development of powerful expression cloning and genome analysis techniques has facilitated the molecular identification and characterization of numerous transporters that play a crucial role in drug disposition. Explaining the principles of drug transport and the associated techniques, Drug Transporters: Molecular Characterization and Role in Drug Disposition: * Provides a comprehensive overview of drug transporters * Includes specific descriptions of transporter families, including substrate and inhibitor specificity, subcellular and tissue localization, mechanisms governing transport, species differences, the clinical implications of these transporters in human physiology and disease, and their role in drug distribution, elimination, and interactions in drug therapy * Describes transporter-mediated drug disposition, a newly emerging field in drug therapy * Gives a comprehensive summary of drug transport across biological membranes * in the liver, brain, kidney, and intestine * Provides balanced coverage of mechanistic aspects and functional outcomes * Features chapters contributed by distinguished scientists in their specialty areas * Provides sufficient detail to enable non-specialists to understand the principles and techniques This authoritative guide is a practical hands-on desk reference for researchers in academia and the pharmaceutical industry and scientists in government agencies. It is also an excellent text for graduate-level courses in the pharmaceutical and pharmacology fields.

Pharmacogenomics In Clinical Practice

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Author : Dragan Primorac
language : en
Publisher: Springer Nature
Release Date : 2024-01-04

Pharmacogenomics In Clinical Practice written by Dragan Primorac and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-04 with Medical categories.

This book provides a practically applicable guide to the applications of pharmogenomics across medicine. Background information is provided on the mechanisms associated with membrane transporters, drug-metabolizing enzymes and their importance in pharmagenomics. Detailed guidance is subsequently presented on how to apply these techniques in disciplines including cardiology, gastroenterology, oncology, transplantation surgery, infectious diseases, anesthesia and analgesia, neurology, psychiatry, primary care, and public health. Clear easy-to-follow instructions are given on how to use big data technologies and public health databases in day-to-day clinical practice. Pharmacogenomics in Clinical Practice concisely covers how pharmacogenomic technologies and techniques can be applied in daily medical practice. It is therefore an ideal up-to-date resource for any medical practitioner, trainee or researcher across all medical disciplines whowant to better understand how to use these techniques.