Pharmacogenomics Of Human Drug Transporters
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Pharmacogenomics Of Human Drug Transporters
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Author : Toshihisa Ishikawa
language : en
Publisher: Wiley
Release Date : 2013-04-15
Pharmacogenomics Of Human Drug Transporters written by Toshihisa Ishikawa and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-15 with Medical categories.
Sets the foundation for safer, more effective drug therapies With this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and development efforts. In particular, the book explains how new findings in the field now enable researchers to more accurately predict drug interactions and adverse drug reactions. Moreover, it sets the foundation for the development of drug therapies that are tailored to an individual patient's genetics. Pharmacogenomics of Human Drug Transporters serves as a comprehensive guide to how transporters regulate the absorption, distribution, and elimination of drugs in the body as well as how an individual's genome affects those processes. The book's eighteen chapters have been authored by a team of leading pioneers in the field. Based on their own laboratory and clinical experience as well as a thorough review of the literature, these authors explore all facets of drug transporter pharmacogenomics, including: Individual drug transporters and transporter families and their clinical significance Principles of altered drug transport in drug–drug interactions, pharmacotherapy, and personalized medicine Emerging new technologies for rapid detection of genetic polymorphisms Clinical aspects of genetic polymorphisms in major drug transporter genes Future research directions of drug transporter pharmacogenomics and the prospect of individualized medicine Pharmacogenomics of Human Drug Transporters opens the door to new drug discovery and development breakthroughs leading to safer and more effective customized drug therapies.The book is recommended for pharmaceutical scientists, biochemists, pharmacologists, clinicians, and genetics and genomics researchers.
Pharmacogenomics Of Membrane Transporters Focus On The Organic Cation Transporter Oct1
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Author : Yan Shu
language : en
Publisher:
Release Date : 2006
Pharmacogenomics Of Membrane Transporters Focus On The Organic Cation Transporter Oct1 written by Yan Shu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
In the final part of this dissertation, the role of OCT1 in hepatic triglyceride homeostasis was explored. A series of assays and measurements were performed in obese (ob/ob) and lean (OB/OB) mice in the presence or absence of the Oct1 allele. The data suggest that in addition to its function as a drug transporter, OCT1 is involved in nutrient, particularly triglyceride and glucose, homeostasis and may be important in the development of fatty liver.
Pharmacogenomics An Introduction And Clinical Perspective
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Author : Joseph S. Bertino
language : en
Publisher: McGraw Hill Professional
Release Date : 2013
Pharmacogenomics An Introduction And Clinical Perspective written by Joseph S. Bertino and has been published by McGraw Hill Professional this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medical categories.
Pharmacogenomics is comprehensive textbook detailing how genetic makeup affects a body's response to drugs.
Membrane Transporters In Drug Discovery And Development
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Author : Qing Yan
language : en
Publisher: Methods in Molecular Biology
Release Date : 2010-04-26
Membrane Transporters In Drug Discovery And Development written by Qing Yan and has been published by Methods in Molecular Biology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-26 with Medical categories.
This text provides practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development.
Pharmacogenomics And Proteomics
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Author : Steven How-Yan Wong
language : en
Publisher: AACC Press
Release Date : 2006
Pharmacogenomics And Proteomics written by Steven How-Yan Wong and has been published by AACC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
Reviews the fundamentals of molecular biology and general clinical implications important in understanding fundamental concepts, a general review of ethical considerations, methods of predicting response using artificial networks, regulatory issues, reimbursement, quality assurance considerations, and future market analysis; methodologies that merge the disciplines of pharmacogenetics with those of proteomics, metabolomics, and metabonomics; specific clinical applications of pharmacogenetics of major drug groups, specialties, and diseases, and how they are linked to potential clinical management; and selected biotechnologies relevant to the application of clinical pharmacogenomics and proteomics to clinical practice.
Pharmacogenetics
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Author : Wendell Weber
language : en
Publisher: Oxford University Press
Release Date : 2008-04-02
Pharmacogenetics written by Wendell Weber and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-02 with Medical categories.
Genes are important modifiers of the human response to drugs, hormones, and toxins. Medical patients and healthy individuals alike display significant differences in response and suffer adverse effects as a result of exposure to many therapeutic agents and occupational chemicals. In this substantially revised second edition, highly regarded authority Wendell Weber brings together laboratory methods and epidemiologic studies in defining the role of heredity in human drug response. The book is divided into two major sections, one covering pharmacognetic concepts and the second the application of those concepts.
Molecular Investigation Of Metabolism And Transport Of Drugs From Animal To Human Tissue
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Author : Johannes Doehmer
language : en
Publisher:
Release Date : 2003
Molecular Investigation Of Metabolism And Transport Of Drugs From Animal To Human Tissue written by Johannes Doehmer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Biology categories.
Pharmacogenomics A Primer For Clinicians
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Author : Jerika T. Lam
language : en
Publisher: McGraw Hill Professional
Release Date : 2020-12-22
Pharmacogenomics A Primer For Clinicians written by Jerika T. Lam and has been published by McGraw Hill Professional this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-22 with Medical categories.
An invaluable resource to the rapidly emerging field of pharmacogenomics—complete with case studies, clinical pearls, and treatment recommendations The aim of pharmacogenomics is to improve personalized medicine by taking into account how genes affect an individual’s tolerability and response to drugs. Approaching pharmacogenomics from the current clinical, scientific, and implementation perspectives, this guide serves as an invaluable evidence-based resource to the subject. Reflecting the shift from genetics to genomics in the pharmaceutical sphere, the book covers pharmacogenomics fundamentals; genotyping tests and evidence; clinical implementation; ethical, legal, and social issues; and more. You’ll also find illuminating case scenarios, clinical pearls, and evidence-based recommendations for treatments and alternatives based on CPIC, PharmGKB, and FDA guidelines.
Tietz Clinical Guide To Laboratory Tests
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Author : Alan H. B. Wu
language : en
Publisher: Saunders
Release Date : 2006
Tietz Clinical Guide To Laboratory Tests written by Alan H. B. Wu and has been published by Saunders this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
Dr. Tietz is retiring his involvement with this publication, and his r eplacement is Dr. Richard McPherson, Chairman of the Department of Pat hology at the Medical College of Virginia. He is very well-respected, serves on the board of CAP, and runs one of the largest university ref erence libraries in the nation. the fourth edition maintains the same overall organization and content that has been so useful to clinical u sers in the past three editions.
Pharmacogenetic Studies Of Membrane Transporters Relevant To Anti Cancer Drug Therapy
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Author : Ilaria Badagnani
language : en
Publisher:
Release Date : 2006
Pharmacogenetic Studies Of Membrane Transporters Relevant To Anti Cancer Drug Therapy written by Ilaria Badagnani and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Membrane transporters are important determinants of drug disposition and response. The goals of this dissertation are to examine the interaction of membrane transporters with anti-cancer drugs, in particular cladribine, fludarabine, and methotrexate, and to analyze their genetic and functional diversity. We showed that the human concentrative nucleoside transporter CNT3 (SLC28A3), which transports nucleoside analogs, is under negative selective pressure. The rare variant, protein reference sequence (p.) Gly367Arg, exhibited reduced transport of nucleosides, whereas common non-synonymous variants of CNT3 exhibited no change in their transport of nucleosides, suggesting that common coding region variants of CNT3 do not contribute to common variation in the efficacy of cladribine and fludarabine. Methotrexate exhibits variable pharmacokinetics and renal toxicity. We showed that the human organic anion transporting polypeptide, OATP1A2 (SLCO1A2 ) transports methotrexate in a pH-dependent manner. Since the human organic anion transporter OAT3 (SLC22A8) and OATP1A2 are expressed in the renal tubule, they may play a role in the elimination and nephrotoxicity of methotrexate. We identified four protein-altering variants in OATP1A2 and six in OAT3 that had altered transport of methotrexate, suggesting that these variants may contribute to variation in the renal disposition and toxicity of methotrexate. We characterized the mechanism of transport and identified critical amino acid residues in OATP1A2 that are responsible for methotrexate uptake. The enhanced transport at acidic pH resulted from increased substrate affinity and did not depend on the proton gradient. Conserved cationic residues in OATP1A2 were important in methotrexate recognition and uptake. Lastly, we initiated collaborative studies to examine the characteristics of methotrexate elimination in patients with acute lymphoblastic leukemia (ALL). Methotrexate pharmacokinetics were non-linear and highly variable. Increased exposure to methotrexate was associated with delayed elimination. In future studies, we will genotype ALL patients for 11 variants and 16 haplotypes in 6 kidney transporters to analyze the contribution of kidney transporters to variation in MTX pharmacokinetics and renal toxicity. These studies have enhanced our understanding of how membrane transporters interact with anti-cancer drugs and, thereby, control their systemic and tissue levels. Genetic variation in these transporters may contribute to variation in the efficacy and toxicity of anti-cancer drugs.