Membrane Protein Bioinformatics
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Structural Bioinformatics Of Membrane Proteins
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Author : D. Frishman
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-01-22
Structural Bioinformatics Of Membrane Proteins written by D. Frishman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-22 with Computers categories.
This book is the first one specifically dedicated to the structural bioinformatics of membrane proteins. With a focus on membrane proteins from the perspective of bioinformatics, the present work covers a broad spectrum of topics in evolution, structure, function, and bioinformatics of membrane proteins focusing on the most recent experimental results. Leaders in the field who have recently reported breakthrough advances cover algorithms, databases and their applications to the subject. The increasing number of recently solved membrane protein structures makes the expert coverage presented here very timely. Structural bioinformatics of membrane proteins has been an active area of research over the last thee decades and proves to be a growing field of interest.
Structural Bioinformatics Of Membrane Proteins
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Author : D. Frishman
language : en
Publisher: Springer
Release Date : 2010-06-29
Structural Bioinformatics Of Membrane Proteins written by D. Frishman and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-29 with Computers categories.
This book is the first one specifically dedicated to the structural bioinformatics of membrane proteins. With a focus on membrane proteins from the perspective of bioinformatics, the present work covers a broad spectrum of topics in evolution, structure, function, and bioinformatics of membrane proteins focusing on the most recent experimental results. Leaders in the field who have recently reported breakthrough advances cover algorithms, databases and their applications to the subject. The increasing number of recently solved membrane protein structures makes the expert coverage presented here very timely. Structural bioinformatics of membrane proteins has been an active area of research over the last thee decades and proves to be a growing field of interest.
Membrane Protein Bioinformatics
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Author : Philip Biggin
language : en
Publisher: CRC PressI Llc
Release Date : 2014-08-01
Membrane Protein Bioinformatics written by Philip Biggin and has been published by CRC PressI Llc this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-01 with Medical categories.
Membrane Protein Structure And Dynamics
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Author : Nagarajan Vaidehi
language : en
Publisher: Humana Press
Release Date : 2012-09-12
Membrane Protein Structure And Dynamics written by Nagarajan Vaidehi and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-12 with Science categories.
Membrane proteins play key roles in numerous cellular processes, in particular mediating cell-to-cell communication and signaling events that lead to a multitude of biological effects. Membrane proteins have also been implicated in many critical diseases such as atherosclerosis, hypertension, diabetes and cancer. In Membrane Protein Structure Predictions Methods: Methods and Protocols, expert researcher in the field detail the advances in both experimental and computational approaches of the structure, dynamics and interactions of membrane proteins dividing the volume into two sections. The first section details the procedures used for measurements of structure and dynamics of membrane proteins. While the second section contains a survey of the computational methods that have played a critical role in membrane protein structure prediction as well as in providing atomic level insight into the mechanism of the dynamics of membrane receptors. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Membrane Protein Structure Predicitons: Methods and Protocols seeks to aid scientists in the further study of membrane protein structure and function.
Membrane Protein Structure Determination
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Author : Jean-Jacques Lacapère
language : en
Publisher: Methods in Molecular Biology
Release Date : 2010-08-06
Membrane Protein Structure Determination written by Jean-Jacques Lacapère and has been published by Methods in Molecular Biology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-08-06 with Science categories.
Membrane proteins, representing nearly 40% of all proteins, are key components of cells involved in many cellular processes, yet only a small number of their structures have been determined. Membrane Protein Structure Determination: Methods and Protocols presents many detailed techniques for membrane protein structure determination used today by bringing together contributions from top experts in the field. Divided into five convenient sections, the book covers various strategies to purify membrane proteins, approaches to get three dimensional crystals and solve the structure by x-ray diffraction, possibilities to gain structural information for a membrane protein using electron microscopy observations, recent advances in nuclear magnetic resonance (NMR), and molecular modelling strategies that can be used either to get membrane protein structures or to move from atomic structure to a dynamic understanding of a molecular functioning mechanism. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and easy to use, Membrane Protein Structure Determination: Methods and Protocols serves as an ideal reference for scientists seeking to further our knowledge of these vital and versatile proteins as well as our overall understanding of the complicated world of cell biology.
Development Of A Suite Of Bioinformatics Tools For The Analysis And Prection Of Membrane Protein Structure
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Author : R. C. Togawa
language : en
Publisher:
Release Date : 2006
Development Of A Suite Of Bioinformatics Tools For The Analysis And Prection Of Membrane Protein Structure written by R. C. Togawa and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
This thesis describes the development of a novel approach for prediction of the three-dimensional structure of transmembrane regions of membrane proteins directly from amino acid sequence and basic transmembrane region topology. The development rationale employed involved a knowledge-based approach. Based on determined membrane protein structures, 20x20 association matrices were generated to summarise the distance associations between amino acid side chains on different alpha helical transmembrane regions of membrane proteins. Using these association matrices, combined with a knowledge-based scale for propensity for residue orientation in transmembrane segments (kPROT) (Pilpel et al., 1999), the software predicts the optimal orientations and associations of transmembrane regions and generates a 3D structural model of a given membrane protein, based on the amino acid sequence composition of its transmembrane regions. During the development, several structural and biostatistical analyses of determined membrane protein structures were undertaken with the aim of ensuring a consistent and reliable association matrix upon which to base the predictions. Evaluation of the model structures obtained for the protein sequences of a dataset of 17 membrane proteins of determined structure based on cross-validated leave-one-out testing revealed general1y high accuracy of prediction, with over 80% of associations between transmembrane regions being correctly predicted. These results provide a promising basis for future development and refinement of the algorithm, and to this end, work is underway using evolutionary computing approaches. As it stands, the approach gives scope for significant immediate benefit to researchers as a valuable starting point in the prediction of structure for membrane proteins of hitherto unknown structure.
Protein Bioinformatics
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Author : M. Michael Gromiha
language : en
Publisher: Academic Press
Release Date : 2011-04-21
Protein Bioinformatics written by M. Michael Gromiha and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-21 with Science categories.
One of the most pressing tasks in biotechnology today is to unlock the function of each of the thousands of new genes identified every day. Scientists do this by analyzing and interpreting proteins, which are considered the task force of a gene. This single source reference covers all aspects of proteins, explaining fundamentals, synthesizing the latest literature, and demonstrating the most important bioinformatics tools available today for protein analysis, interpretation and prediction. Students and researchers of biotechnology, bioinformatics, proteomics, protein engineering, biophysics, computational biology, molecular modeling, and drug design will find this a ready reference for staying current and productive in this fast evolving interdisciplinary field. - Explains all aspects of proteins including sequence and structure analysis, prediction of protein structures, protein folding, protein stability, and protein interactions - Presents a cohesive and accessible overview of the field, using illustrations to explain key concepts and detailed exercises for students.
The Ten Most Wanted Solutions In Protein Bioinformatics
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Author : Anna Tramontano
language : en
Publisher: CRC Press
Release Date : 2005-05-24
The Ten Most Wanted Solutions In Protein Bioinformatics written by Anna Tramontano and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-05-24 with Mathematics categories.
Utilizing high speed computational methods to extrapolate to the rest of the protein universe, the knowledge accumulated on a subset of examples, protein bioinformatics seeks to accomplish what was impossible before its invention, namely the assignment of functions or functional hypotheses for all known proteins.The Ten Most Wanted Solutions in Pro
Encyclopedia Of Genetics Genomics Proteomics And Bioinformatics 8 Volume Set
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Author : Michael J. Dunn
language : en
Publisher: Wiley
Release Date : 2005-11-11
Encyclopedia Of Genetics Genomics Proteomics And Bioinformatics 8 Volume Set written by Michael J. Dunn and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-11 with Science categories.
Available in print and online, this unique reference brings together all four fields of genetics, genomics, proteomics, and bioinformatics to meet your dynamic research requirements. It brings together the latest concepts in these vibrant areas and ensures a truly multidisciplinary approach. Topics include genetic variation and evolution, epigenetics, the human genome, expression profiling, proteome families, structural proteomics, gene finding/gene structure, protein function and annotation, and more. The work incorporates a vast amount of topical information, profiles cutting-edge techniques, and presents the very latest findings from an international team of over five hundred contributors. With articles for both students and more experienced scientists, this is a key reference source for everyone. Contains more than 450 articles covering all aspects of genomics, proteomics, bioinformatics and related technologies Includes a glossary containing over 550 clear and concise definitions "I am pleased to recommend it heartily as a essential reference tool...should remain the definitive work...for many years to come." THE CHEMICAL EDUCATOR "Jorde...and co-editors have done a remarkable job in coordinating this information, distilling it into a package that is both easy to navigate and over-flowing in discovery." ELECTRIC REVIEW
Computational Biophysics Of Membrane Proteins
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Author : Carmen Domene
language : en
Publisher: Royal Society of Chemistry
Release Date : 2016-11-30
Computational Biophysics Of Membrane Proteins written by Carmen Domene and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-30 with Science categories.
Exploring current themes in modern computational and membrane protein biophysics, this book presents a comprehensive account of the fundamental principles underlying different methods and techniques used to describe the intriguing mechanisms by which membrane proteins function. The book discusses the experimental approaches employed to study these proteins, with chapters reviewing recent crucial structural advances that have allowed computational biophysicists to discern how these molecular machines work. The book then explores what computational methods are available to researchers and what these have taught us about three key families of membrane proteins: ion channels, transporters and receptors. The book is ideal for researchers in computational chemistry and computational biophysics.