Membrane Lipid Oxidation

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Membrane Lipid Oxidation

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Author : Carmen Vigo-Pelfrey
language : en
Publisher: CRC-Press
Release Date : 1990-11-26

Membrane Lipid Oxidation written by Carmen Vigo-Pelfrey and has been published by CRC-Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-11-26 with Science categories.

This two-volume text compiles the efforts of distinguished scientists nd focuses on the formation of free radicals, toxic effects of lipoperoxides, biological antioxidant protection against lipid peroxidation damage, and pathological implications of lipid peroxidation. This review also addresses vitamin E deficiency, carbon tetrachloride and ethanol poisoning, radiation damage, hyperbaric effects, tumors, aging, diabetes, liver degeneration, DNA damage, lipoprotein modification and artherosclerosis, multiple sclerosis, angiopathy, Parkinson's disease, lupus, and many other degenerative diseases. It is an excellent resource for biological chemist, cell biologists, and all who are interested in the pharmaceutical sciences.

Impact Of Lipid Peroxidation On The Physiology And Pathophysiology Of Cell Membranes

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Author : Angel Catalá
language : en
Publisher: Frontiers Media SA
Release Date : 2017-01-17

Impact Of Lipid Peroxidation On The Physiology And Pathophysiology Of Cell Membranes written by Angel Catalá and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-17 with categories.

The general process of lipid peroxidation consists of three stages: initiation, propagation, and termination. The initiation phase of lipid peroxidation includes hydrogen atom abstraction. Several species can abstract the first hydrogen atom and include the radicals: hydroxyl, alkoxyl, peroxyl, and possibly HO* 2. The membrane lipids, mainly phospholipids, containing polyunsaturated fatty acids are predominantly susceptible to peroxidation because abstraction from a methylene group of a hydrogen atom, which contains only one electron, leaves at the back an unpaired electron on the carbon. The initial reaction of *OH with polyunsaturated fatty acids produces a lipid radical (L*), which in turn reacts with molecular oxygen to form a lipid hydroperoxide (LOOH). Further, the LOOH formed can suffer reductive cleavage by reduced metals, such as Fe++, producing lipid alkoxyl radical (LO*). Peroxidation of lipids can disturb the assembly of the membrane, causing changes in fluidity and permeability, alterations of ion transport and inhibition of metabolic processes. In addition, LOOH can break down, frequently in the presence of reduced metals or ascorbate, to reactive aldehyde products, including malondialdehyde (MDA), 4-hydroxy-2-nonenal (HNE), 4-hydroxy-2-hexenal (4-HHE) and acrolein. Lipid peroxidation is one of the major outcomes of free radical-mediated injury to tissue mainly because it can greatly alter the physicochemical properties of membrane lipid bilayers, resulting in severe cellular dysfunction. In addition, a variety of lipid by-products are produced as a consequence of lipid peroxidation, some of which can exert beneficial biological effects under normal physiological conditions. Intensive research performed over the last decades have also revealed that by-products of lipid peroxidation are also involved in cellular signalling and transduction pathways under physiological conditions, and regulate a variety of cellular functions, including normal aging. In the present collection of articles, both aspects (adverse and benefitial) of lipid peroxidation are illustrated in different biological paradigms. We expect this eBook may encourage readers to expand the current knowledge on the complexity of physiological and pathophysiological roles of lipid peroxidation.

Role Of Membrane Lipid Oxidation In Cold Acclimation

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Author : Gila Ben-Yehuda
language : en
Publisher:
Release Date : 1997

Role Of Membrane Lipid Oxidation In Cold Acclimation written by Gila Ben-Yehuda and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.

Lipid Oxidation In Food

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Author : Allen J. St. Angelo
language : en
Publisher:
Release Date : 1992

Lipid Oxidation In Food written by Allen J. St. Angelo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Language Arts & Disciplines categories.

Developed from a symposium at the 202nd National Meeting of the ACS, New York City, August 1991, this volume contains 20 papers in the areas of mechanisms of free-radical processes, prevention of lipid oxidation, methodologies for assessing lipid oxidation products, and processing effects on lipid oxidation. Commodities covered include beef, pork, fresh and saltwater fish, peanuts, vegetable oils, and baby foods. Annotation copyright by Book News, Inc., Portland, OR

Membranal Lipid Oxidation In Muscle Tissue Mechanism And Prevention

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Author : Nicki Jene Engeseth
language : en
Publisher:
Release Date : 1990

Membranal Lipid Oxidation In Muscle Tissue Mechanism And Prevention written by Nicki Jene Engeseth and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Cholesterol categories.

Lipid Peroxidation In Poultry Meat And Its Subcellular Membranes As Influenced By Dietary Oils And Antioxidant Supplementation

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Author : Charles Fley-Fung Lin
language : en
Publisher:
Release Date : 1988

Lipid Peroxidation In Poultry Meat And Its Subcellular Membranes As Influenced By Dietary Oils And Antioxidant Supplementation written by Charles Fley-Fung Lin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Antioxidants categories.

The Rold Of Membrane Lipids In Low Temperature Adaptation Of Plants

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Author : Daryl G. Richardson
language : en
Publisher:
Release Date : 1975

The Rold Of Membrane Lipids In Low Temperature Adaptation Of Plants written by Daryl G. Richardson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975 with categories.

Reactive Oxygen Species Lipid Peroxidation And Protein Oxidation

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Author : Angel Catalá
language : en
Publisher: Nova Science Publishers
Release Date : 2014

Reactive Oxygen Species Lipid Peroxidation And Protein Oxidation written by Angel Catalá and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Active oxygen categories.

Many studies have shown that free radical damage and lipid peroxidation increase as a function of the degree of unsaturation of the fatty acids present in the phospholipids of biological membranes. Membrane phospholipids are particularly susceptible to oxidation not only because of their highly polyunsaturated fatty acid content but also because of their association in the cell membrane with non-enzymatic and enzymatic systems capable of generating pro-oxidative-free radical species. There are two broad outcomes to lipid peroxidation: structural damage to membranes and generation of secondary products. Membrane damage derives from the generation of fragmented fatty acyl chains, lipidlipid cross-links, lipidprotein cross-links and endocyclisation to produce isoprostanes and neuroprostanes. These processes combine to produce changes in the biophysical properties of membranes that can have profound effects on the activity of membrane-bound proteins. The consequence of peroxidation of unsaturated fatty acids is severe: damage of membranes function, enzymatic inactivation, toxic effects on the cellular division, etc. This new book presents and discusses current research on oxidative stress, and lipid oxidation non-inhibited and inhibited; assessment of oxidative balance in the lipo- and hydro-philic cellular environment in biological systems; mass spectrometry detection of protein modification by cross-reaction with lipid peroxidation products; diagonal gel electrophoretic analysis of protein disulfides: principles and applications. Other chapters describe: heavy metals exposure and cells oxidative damage; biodegradation of metallic biomaterials: its relation with the generation of reactive oxygen species; Oxidative modifications of proteins in the aging heart; role of reactive oxygen species as signalling molecules involved in the regulation of physiological processes of the nervous system; oxidative stress in diabetes and hypertension treated with alternative therapy of medicinal plants; impairment of redox homeostasis of tissue damage in inborn errors of metabolism with intoxication: insights from human and animal studies and finally lipid peroxidation of phospholipids in the vertebrate retina or in liposomes made of retinal lipids: similarities and differences are described.

Effects Of Dietary Antioxidant Treatments On Lipid Oxidation In A Simulated Stomach And Circulating Blood Lipids

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Author : Matthew Kuffa
language : en
Publisher:
Release Date : 2006

Effects Of Dietary Antioxidant Treatments On Lipid Oxidation In A Simulated Stomach And Circulating Blood Lipids written by Matthew Kuffa and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.

Lipid Peroxidation

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Author : John A. Buege
language : en
Publisher:
Release Date : 1976

Lipid Peroxidation written by John A. Buege and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with Iron categories.