Lipid Peroxidation
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Impact Of Lipid Peroxidation On The Physiology And Pathophysiology Of Cell Membranes
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Author : Angel Catalá
language : en
Publisher: Frontiers Media SA
Release Date : 2017-01-17
Impact Of Lipid Peroxidation On The Physiology And Pathophysiology Of Cell Membranes written by Angel Catalá and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-17 with categories.
The general process of lipid peroxidation consists of three stages: initiation, propagation, and termination. The initiation phase of lipid peroxidation includes hydrogen atom abstraction. Several species can abstract the first hydrogen atom and include the radicals: hydroxyl, alkoxyl, peroxyl, and possibly HO* 2. The membrane lipids, mainly phospholipids, containing polyunsaturated fatty acids are predominantly susceptible to peroxidation because abstraction from a methylene group of a hydrogen atom, which contains only one electron, leaves at the back an unpaired electron on the carbon. The initial reaction of *OH with polyunsaturated fatty acids produces a lipid radical (L*), which in turn reacts with molecular oxygen to form a lipid hydroperoxide (LOOH). Further, the LOOH formed can suffer reductive cleavage by reduced metals, such as Fe++, producing lipid alkoxyl radical (LO*). Peroxidation of lipids can disturb the assembly of the membrane, causing changes in fluidity and permeability, alterations of ion transport and inhibition of metabolic processes. In addition, LOOH can break down, frequently in the presence of reduced metals or ascorbate, to reactive aldehyde products, including malondialdehyde (MDA), 4-hydroxy-2-nonenal (HNE), 4-hydroxy-2-hexenal (4-HHE) and acrolein. Lipid peroxidation is one of the major outcomes of free radical-mediated injury to tissue mainly because it can greatly alter the physicochemical properties of membrane lipid bilayers, resulting in severe cellular dysfunction. In addition, a variety of lipid by-products are produced as a consequence of lipid peroxidation, some of which can exert beneficial biological effects under normal physiological conditions. Intensive research performed over the last decades have also revealed that by-products of lipid peroxidation are also involved in cellular signalling and transduction pathways under physiological conditions, and regulate a variety of cellular functions, including normal aging. In the present collection of articles, both aspects (adverse and benefitial) of lipid peroxidation are illustrated in different biological paradigms. We expect this eBook may encourage readers to expand the current knowledge on the complexity of physiological and pathophysiological roles of lipid peroxidation.
Oxidants Antioxidants And Free Radicals
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Author : Steven Baskin
language : en
Publisher: CRC Press
Release Date : 1997-11-12
Oxidants Antioxidants And Free Radicals written by Steven Baskin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-11-12 with Medical categories.
This volume collates articles investigating antioxidant, oxidant and free radical research. It examines the role of such research in health and disease, particulary with respect to developing greater understanding about the many interactions between oxidants and antioxidants, and how such substances may act as natural protectants and /or natural toxicants.
Superoxide Ion
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Author : Igor B. Afanas'ev
language : en
Publisher: CRC Press
Release Date : 1991-04-23
Superoxide Ion written by Igor B. Afanas'ev and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-04-23 with Medical categories.
The chemical properties of superoxide ion, its biological role, and the role of other oxygen radicals which arise as a result of its transformations are contained in this text. In Volume I the principal reactions of superoxide ion, including protonation reactions with proton donors, nucleophilic reactions with esters, alkyl halides and other compounds, electron transfer reactions with quinones and metal complexes, are described. Basic quantitative data including rate constants and yields for the reactions of superoxide ion of all types are given in tables. This volumecontains the mechanisms of the generation of oxygen radicals in cells and the interaction of superoxide ion with cell components. The role of superoxide ion in lipid peroxidation and destruction of proteins and nucleic acids is explained, as well as oxygen radicals in the mechanisms of toxic and therapeutic action of drugs, especially anticancer antibiotics. In addition, the action of superoxide ion and other oxygen radicals on plants, micro-, and macroorganisms is discussed, along with the role of oxygen radicals in normal metabolic and pathological processes.
Nitric Oxide
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Author : Louis J. Ignarro
language : en
Publisher: Academic Press
Release Date : 2000-09-13
Nitric Oxide written by Louis J. Ignarro and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-09-13 with Medical categories.
Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems. NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells. NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis. This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications. - Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide - Authored by world experts on nitric oxide - Includes an overview of basic principles of biology and chemical biology - Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense
Lipid Peroxidation
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Author : John A. Buege
language : en
Publisher:
Release Date : 1976
Lipid Peroxidation written by John A. Buege and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with Iron categories.
Lipid Oxidation
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Author : Edwin N. Frankel
language : en
Publisher: Elsevier
Release Date : 2014-01-23
Lipid Oxidation written by Edwin N. Frankel and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-23 with Technology & Engineering categories.
In this second edition, Edwin Frankel has updated and extended his now well-known book Lipid oxidation which has come to be regarded as the standard work on the subject since the publication of the first edition seven years previously. His main objective is to develop the background necessary for a better understanding of what factors should be considered, and what methods and lipid systems should be employed, to achieve suitable evaluation and control of lipid oxidation in complex foods and biological systems. The oxidation of unsaturated fatty acids is one of the most fundamental reactions in lipid chemistry. When unsaturated lipids are exposed to air, the complex, volatile oxidation compounds that are formed cause rancidity. This decreases the quality of foods that contain natural lipid components as well as foods in which oils are used as ingredients. Furthermore, products of lipid oxidation have been implicated in many vital biological reactions, and evidence has accumulated to show that free radicals and reactive oxygen species participate in tissue injuries and in degenerative disease. Although there have been many significant advances in this challenging field, many important problems remain unsolved. This second edition of Lipid oxidation follows the example of the first edition in offering a summary of the many unsolved problems that need further research. The need to understand lipid oxidation is greater than ever with the increased interest in long-chain polyunsaturated fatty acids, the reformulation of oils to avoid hydrogenation and trans fatty acids, and the enormous attention given to natural phenolic antioxidants, including flavonoids and other phytochemicals.
Lipid Peroxidation In Poultry Meat And Its Subcellular Membranes As Influenced By Dietary Oils And Antioxidant Supplementation
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Author : Charles Fley-Fung Lin
language : en
Publisher:
Release Date : 1988
Lipid Peroxidation In Poultry Meat And Its Subcellular Membranes As Influenced By Dietary Oils And Antioxidant Supplementation written by Charles Fley-Fung Lin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Antioxidants categories.
The Role Of Xenobiotic Metabolism And Lipid Peroxidation In Hepatotoxicity In The Rat And Trout
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Author : Yasmin Singh
language : en
Publisher:
Release Date : 1991
The Role Of Xenobiotic Metabolism And Lipid Peroxidation In Hepatotoxicity In The Rat And Trout written by Yasmin Singh and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with categories.
Lipid Peroxides In Biology And Medicine
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Author : Kunio Yagi
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Lipid Peroxides In Biology And Medicine written by Kunio Yagi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Lipid Peroxides in Biology and Medicine emphasizes the importance of the control of lipid peroxides in the body for the prevention and treatment of degenerative diseases. This book discusses the production of free radicals in vivo from the action of xenobiotics, and comparative aspects of several model lipid peroxidation systems. The lipid peroxidation and membrane alterations in erythrocyte survival, and lipid peroxidations of cholesterol are also deliberated. This text likewise covers the mechanism of protection against membrane peroxidation, lipid peroxides as a cause of vascular diseases, and peroxide-mediated metabolic activation of carcinogens. Other topics include lipid peroxide in aging process and production of ethane and pentane during lipid peroxidation. This publication is valuable to biologists, medical practitioners, and clinicians researching on lipid peroxides.
Effect Of Endotoxin On Lipid Peroxidation In Selenium And Vitamin E Deficient And Adequate Rats
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Author : John Thomas Sword
language : en
Publisher:
Release Date : 1987
Effect Of Endotoxin On Lipid Peroxidation In Selenium And Vitamin E Deficient And Adequate Rats written by John Thomas Sword and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with categories.