Human Epigenetics How Science Works
DOWNLOAD
Download Human Epigenetics How Science Works PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Human Epigenetics How Science Works book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Human Epigenetics How Science Works
DOWNLOAD
Author : Carsten Carlberg
language : en
Publisher: Springer Nature
Release Date : 2019-09-24
Human Epigenetics How Science Works written by Carsten Carlberg and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-24 with Medical categories.
The view “It’s all in our genes and we cannot change it” developed in the past 150 years since Gregor Mendel’s experiments with flowering pea plants. However, there is a special form of genetics, referred to as epigenetics, which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes dynamically throughout our whole life. Thus, we have the chance to change our epigenetics in a positive as well as negative way and present the onset of diseases, such a type 2 diabetes or cancer. This textbook provides a molecular explanation how our genome is connected with environmental signals. It outlines that epigenetic programming is a learning process that results in epigenetic memory in each of the cells of our body. The central importance of epigenetics during embryogenesis and cellular differentiation as well as in the process of aging and the risk for the development of cancer are discussed. Moreover, the role of the epigenome as a molecular storage of cellular events not only in the brain but also in metabolic organs and in the immune system is described. The book represents an updated but simplified version of our textbook “Human Epigenomics” (ISBN 978-981-10-7614-8). The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease.
Molecular Medicine
DOWNLOAD
Author : Carsten Carlberg
language : en
Publisher: Springer Nature
Release Date : 2023-04-18
Molecular Medicine written by Carsten Carlberg and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-18 with Medical categories.
The fascinating area of molecular medicine provides a molecular and cellular description of health and disease. Starting with the understanding of gene regulation and epigenetics, i.e., the interplay of transcription factors and chromatin, this book will provide an fundamental basis of nearly all processes in physiology, both in health as well as in most common disorders, such as cancer, diabetes as well as in autoimmune diseases. Most non-communicable human diseases have a genetic (= inherited) as well as an epigenetic component. The later one is based on our lifestyle choices and environmental exposures. Many common diseases, such as type 2 diabetes, can be explained only to some 20% via a genetic predisposition. We cannot change the genes that we are born with but we can take care of the remaining 80% being primarily based on our epigenome. Therefore, there is a high level of individual responsibility for staying healthy. Thus, not only biologists and biochemists should be aware of this topic, but all students of biomedical disciplines will benefit from being introduced into the concepts of molecular medicine. This will provide them with a good basis for their specialized disciplines of modern life science research. The book is subdivided into 42 chapters that are linked to a series of lecture courses in “Molecular Medicine and Genetics”, “Molecular Immunology”, “Cancer Biology” and “Nutrigenomics” that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. This book represents an updated version and fusion of the books textbooks “Mechanisms of Gene Regulation: How Science Works” (ISBN 978-3-030-52321-3), “Human Epigenetics: How Science Works” (ISBN 978-3-030-22907-8). “Molecular Immunology: How Science Works” (ISBN 978-3-031-04024-5), “Cancer Biology: How Science Works” (ISBN 978-3-030-75699-4) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4). By combining basic understanding of cellular mechanism with clinical examples, the authors hope to make this textbook a personal experience. A glossary in the appendix will explain the major specialist’s terms.
Gene Regulation And Epigenetics
DOWNLOAD
Author : Carsten Carlberg
language : en
Publisher: Springer Nature
Release Date : 2024-10-04
Gene Regulation And Epigenetics written by Carsten Carlberg and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-04 with Science categories.
This book delves into the fascinating realm of eukaryotic gene regulation. The specific expression of genes shapes the phenotype of cells and tissues. The regulation of gene expression, including up- and downregulation, is a fundamental aspect of nearly all physiological processes, both in health and disease. These dynamic processes respond to various daily challenges, such as dietary changes and infections. Therefore, it is crucial for not only biologists and biochemists but also all students in biomedical disciplines to understand gene regulation concepts. This foundational knowledge will benefit them in their specialized fields. A comprehensive understanding of transcription factors and the mechanisms that alter their activity is a fundamental goal of modern life science research. Epigenetics refers to the packaging and accessibility of the genome in each of the trillions of cells in our bodies. The prefix “epi” (meaning “upon,” “above,” or “beyond”) indicates that epigenetic processes do not alter the DNA sequence of our genome, adding a layer of information beyond that encoded in our genome. Genomic DNA is wrapped around complexes of histone proteins, helping it fit into a cell nucleus with a diameter of less than 10 μm. This protein-DNA complex is known as chromatin. The content of this book is linked to the “Molecular Medicine and Genetics” course, which the author has lectured on in various forms since 2002 at the University of Eastern Finland in Kuopio. This book is an updated version of the textbooks “Mechanisms of Gene Regulation” and “Human Epigenomics.” It is divided into 16 chapters. Following two introductory chapters, four chapters explore gene regulation from the perspective of transcription factors, while another four chapters focus on chromatin and non-coding RNA. Three chapters then discuss the impact of epigenetics from a health perspective, and the final three chapters address epigenetics from the perspective of diseases. A glossary in the appendix explains the major specialist terms.
Science
DOWNLOAD
Author : John Michels (Journalist)
language : en
Publisher:
Release Date : 2004
Science written by John Michels (Journalist) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Science categories.
A weekly record of scientific progress.
Longevity Made Simple
DOWNLOAD
Author : Shad Marvasti
language : en
Publisher: Simon and Schuster
Release Date : 2026-01-20
Longevity Made Simple written by Shad Marvasti and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2026-01-20 with Health & Fitness categories.
What if aging didn’t mean decline—and chronic disease wasn’t inevitable? Longevity Made Simple: Live Healthier for Longer with the DRESS Code is a transformative guide that challenges everything we think we know about health, aging, and the future of medicine. A Stanford-trained physician and leading expert in lifestyle and integrative medicine, Dr. Shad reveals the truth: we don’t have a healthcare system—we have a sick care system, one that reacts to disease rather than prevents it. Meanwhile, chronic conditions like heart disease, diabetes, obesity, and many cancers continue to cut lives short—despite being largely preventable. Longevity Made Simple empowers you to take your health into your own hands using the DRESS Code—Diet, Relationships, Exercise, Stress, and Sleep—a practical, science-based blueprint to prevent, treat, and even reverse the chronic diseases that account for most premature, preventable deaths worldwide. Backed by the latest research in epigenetics, Dr. Shad explains in clear, accessible language how your genes are not your fate. Instead, your lifestyle choices can change the expression of your genes, tackling the root causes of disease and promoting optimal health and vitality as you age. You’ll learn: - What the latest science reveals about the food and habits that help you thrive - Why connection and community may be more vital than any supplement - How to optimize your sleep, tame stress, and move with joy - Actionable strategies and routines that fit into real life—no matter your age or background
Cancer Biology How Science Works
DOWNLOAD
Author : Carsten Carlberg
language : en
Publisher: Springer Nature
Release Date : 2021-07-05
Cancer Biology How Science Works written by Carsten Carlberg and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-05 with Medical categories.
Cancer is a collection of diseases that can affect basically every organ of our body, all of which have in common uncontrolled cellular growth. The cells forming our body have the potential to grow in the context of wound healing or for the constant replacement of cells in our blood, skin or intestine. Behind every newly diagnosed malignant tumor in adulthood there is an individual history of probably 20 or more years of tumorigenesis. Therefore, malignant tumor formation often takes time making cancer in most cases to an aging-related disease that we seem not to be able to evade. However, tumorigenesis is dependent on multiple environmental influences, many of which we have under control by lifestyle decisions, such as retaining from smoking, selecting healthy food and being physically active. Thus, cancer preventive interventions are the most effective way to fight against cancer. This textbook wants not only to describe basic mechanisms leading to cancer but also to provide the readers with a more holistic view including cancer surveaillance mechanisms of the immune system. We will place these insights in the context of the personal consequences of everyone’s lifestyle decisions. The content of the book is linked to the lecture course in “Cancer Biology”, which is given by Prof. Carlberg since 2005 at the University of Eastern Finland in Kuopio. Moreover, biological processes explained in this book will be set into a clinical context using the experience of Dr. Velleuer in the daily care in oncology. This book also relates to the textbooks “Mechanisms of Gene Regulation: How Science Works” (ISBN 978-3-030-52321-3), “Human Epigenetics: How Science Works” (ISBN 978-3-030-22907-8) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4), the studying of which may be interesting to readers who like to get more detailed information.
Bioethics
DOWNLOAD
Author : T. B. Mepham
language : en
Publisher:
Release Date : 2008-03-13
Bioethics written by T. B. Mepham and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-13 with Business & Economics categories.
Ben Mepham is Special Professor in Applied Bioethics, School of Biosciences, University of Nottingham and Visiting Professor in Bioethics, Department of Policy Studies, University of Lincoln, UK. I. The Theoretical Background to Bioethics 1. The Nature of Bioethics 2. Theories of Ethics 3. A Framework for Ethical Analysis II. Bioethics and Human Futures 4. The Biology of Poverty 5. Fertility and Morality 6. Genomics, Eugenics and Integrity III. Bioethics and Animals 7. Human Uses of Animals 8. Experiments on Animals 9. Animals and Modern Biotechnology IV. Bioethics, Plants, and the Environment 10. The First Generation of Genetically Modified Crops 11. Dietary Futures 12. Environmental Sustainability V. Bioethics in Practice 13. Risk, Precaution, and Trust 14. Politics and the Biosciences 15. Bioethics in the Laboratory
Scientific American
DOWNLOAD
Author :
language : en
Publisher:
Release Date : 2003
Scientific American written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Science categories.
Human Ecology
DOWNLOAD
Author :
language : en
Publisher:
Release Date : 2005
Human Ecology written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Electronic journals categories.
The Bulletin
DOWNLOAD
Author :
language : en
Publisher:
Release Date : 2007
The Bulletin written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Sydney (N.S.W.) categories.