Dna Encoded Libraries
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Dna Encoded Libraries
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Author : Andreas Brunschweiger
language : en
Publisher: Springer Nature
Release Date : 2022-11-25
Dna Encoded Libraries written by Andreas Brunschweiger and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-25 with Science categories.
This book deals with the recent advances in DNA-Encoded Library (DEL) technology that has emerged as an alternative to high throughput screening (HTS) over the last decade and has been heralded as a "disruptive" technology for drug discovery. The book aims to provide a comprehensive overview of all of the major components of the DEL process from conception to bench execution and clinical investigations. The contributions from experts in the field combine different perspectives from academia and industry. The book will be of interest to researchers in the drug discovery field as well as to graduate students and scholars who are interested in this rapidly improving technology.
A Handbook For Dna Encoded Chemistry
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Author : Robert A. Goodnow, Jr.
language : en
Publisher: John Wiley & Sons
Release Date : 2014-04-10
A Handbook For Dna Encoded Chemistry written by Robert A. Goodnow, Jr. and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-10 with Science categories.
This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry – synthetic and analytical chemistry, molecular biology, informatics, and biochemistry Shows medicinal and pharmaceutical chemists how to efficiently broaden available "chemical space" for drug discovery Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods
Dna Encoded Library Technology For Drug Discovery
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Author : Guansai Liu
language : en
Publisher: Royal Society of Chemistry
Release Date : 2025-02-21
Dna Encoded Library Technology For Drug Discovery written by Guansai Liu and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-21 with Science categories.
DNA-encoded libraries have numerous advantages over traditional screening methods, including easy identification of compounds and the large quantity of compounds that can be screened simultaneously. This book provides a comprehensive guide to the implementation of DNA-encoded library technology (DELT) in drug discovery for screening and hit validation, illustrated with successful case studies. A valuable resource for researchers in drug discovery, this book is complete with successful case studies to illustrate the best practice in implementation and operation of DELT.
Dna Encoded Chemical Libraries
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Author : David Israel
language : en
Publisher: Springer Nature
Release Date : 2022-09-09
Dna Encoded Chemical Libraries written by David Israel and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-09 with Science categories.
This volume discusses protocols that cover synthesis, screening by selection, and analysis of DNA-encoded chemical libraries (DEL). Chapters in this book focus on methods used to practice DEL technology and include solution phase library synthesis using a variety of chemistries; DNA encoding of chemical structure; design, preparation and analysis of target proteins and tool compounds; screening of soluble protein targets by affinity selection; DEL qPCR, preparative PCR and DNA sequence analysis; computational methods used to analyze selections and choose compounds for resynthesis; and analysis of hit compounds. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, DNA-Encoded Chemical Libraries: Methods and Protocols is a valuable resource for scientists interested in DEL technology for drug discovery, and will contribute to the continued advancement in this important field.
Computational Methodologies For Dna Encoded Libraries
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Author : Silvia Chines
language : en
Publisher:
Release Date : 2022
Computational Methodologies For Dna Encoded Libraries written by Silvia Chines and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
Dna Encoded Chemical Libraries
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Author : Christoph Erich Dumelin
language : en
Publisher:
Release Date : 2007
Dna Encoded Chemical Libraries written by Christoph Erich Dumelin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Dna Encoded Chemical Libraries
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Author : Luca Mannocci
language : en
Publisher:
Release Date : 2009
Dna Encoded Chemical Libraries written by Luca Mannocci and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Drug Discovery And Development Third Edition
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Author : James J. O'Donnell
language : en
Publisher: CRC Press
Release Date : 2019-11-21
Drug Discovery And Development Third Edition written by James J. O'Donnell and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-21 with Medical categories.
Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features: Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries Case study detailing the discovery of the anti-cancer drug, lorlatinib Venture capitalist commentary on trends and best practices in drug discovery and development Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in Research Contributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business
Development Of Synthesis Methodology For Dna Encoded Libraries
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Author : Mateja Klika Škopić
language : en
Publisher:
Release Date : 2017
Development Of Synthesis Methodology For Dna Encoded Libraries written by Mateja Klika Škopić and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Peptide Libraries
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Author : Hans Michael Maric
language : en
Publisher: Springer Nature
Release Date : 2025-08-16
Peptide Libraries written by Hans Michael Maric and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-08-16 with Science categories.
This volume provides a collection of novel and emerging methods for the generation and application of peptide libraries. Chapter focus on methods and techniques highlighting new avenues for library screening. Written in the Methods in Molecular Biology series format, chapters outline strategies and overview their area or describe specific applications of the method including an introduction, the necessary materials, step-by-step, readily reproducible laboratory and computational protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Peptide Libraries: Methods and Protocols aims to be comprehensive guide for researchers in the field.