Thrombolysis

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Thrombolytic Therapy For Acute Stroke

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Author : Patrick D. Lyden
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-08

Thrombolytic Therapy For Acute Stroke written by Patrick D. Lyden and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-08 with Medical categories.

It often takes time for a new therapeutic modality to mature into an accepted treatment option. After initial approval, new drugs, devices, and procedures all go through this process until they become “vetted” by the scientific community as well as the medical community at large. Thrombolysis for treatment of stroke is no exception. Thrombolytic Therapy for Acute Stroke, Second Edition comes four years after the first edition and provides a very comprehensive, updated perspective on the use of intravenous rt-TPA in acute stroke. The authors provide longer term follow-up on the pivotal clinical trials that led to Food and Drug Administration approval, data concerning phase 4 trials in larger numbers of patients, and, most importantly, the community experience that has accumulated since its release. They add to this the latest promising information concerning intra-arterial thrombolysis, which is still under investigation and more speculative sections concerning possible new avenues of clinical research such as combining intravenous thr- bolysis with neuroprotective therapies or intra-arterial thrombolysis. A wealth of factual information is supplemented by chapters containing sage opinion from Drs. Lyden and Caplan concerning the logistical, economic, and procedural issues that have been generated since the advent of this technology. Importantly, diagnosis does not take a back seat to therapeutics as illustrated by sections devoted to eva- ation of the stroke patient, very useful illustrative cases and clinical comments, and chapters on the latest in imaging as applied to this field.

Thrombolytic Therapy For Stroke

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Author : Patrick D. Lyden
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-02-23

Thrombolytic Therapy For Stroke written by Patrick D. Lyden and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-02-23 with Medical categories.

Thrombolytic Therapy for Stroke is intended for physicians who will be treating patients in the first few hours after stroke: neurologists, neurosurgeons, emergency medicine physicians, internists, and radiologists. In some areas, fam ily medicine general practice physicians may provide the majority of acute stroke care. We will provide the reader with all the data necessary to understand the utility and limitations of thrombolytic therapy. By reading the protocols, and working through the case tutorials, the reader will become sufficiently familiar with the indications and contraindications of thrombolytic therapy to begin evalu ating potential patients. Although nothing can replace direct instruction by more experienced physicians, we hope that by imparting our accumulated knowledge we may guide those physicians who cannot attend a "hands-on" workshop, or who, having heard the appropriate lectures, feel the need for further guidance. We will review the scientific rationale for thrombolysis: first, most ischemic stroke is caused by thrombo-emboli; second, a portion of brain, the penumbra, remains salvageable for a few hours after vascular occlusion; and third, promptly delivered thrombolysis can remove the offending occlusion and restore cerebral blood flow to the penumbra in time to salvage brain and neurologic function. Then we will review the preclinical development of thrombolytics for stroke pa tients and the early pilot trials. Next, we will present the pivotal clinical trials that demonstrated the efficacy and safety of thrombolysis.

Thrombolysis

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Author : Désiré Collen
language : en
Publisher:
Release Date : 1985

Thrombolysis written by Désiré Collen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Medical categories.

Thrombolysis In Cardiovascular Disease

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Author : Desmond Gareth Julian
language : en
Publisher:
Release Date : 1989

Thrombolysis In Cardiovascular Disease written by Desmond Gareth Julian and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Medical categories.

New Therapeutic Agents In Thrombosis And Thrombolysis

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Author : Arthur Asao Sasahara
language : en
Publisher: CRC Press
Release Date : 1997

New Therapeutic Agents In Thrombosis And Thrombolysis written by Arthur Asao Sasahara and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.

Focuses on pharmaceutical agents that have advanced to Phase II of clinical testing or that hold significant promise in the field of therapeutics. The text provides a review of the basic mechanisms, clinical developments and applications of therapeutic agents in thrombosis and thrombolysis. It also offers chapters that feature executive summaries and results from preclinical investigations and Phase I or II clinical studies.

Thrombolysis In Pulmonary Embolism

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Author : Carlos Jerjes-Sánchez
language : en
Publisher: Springer
Release Date : 2015-08-26

Thrombolysis In Pulmonary Embolism written by Carlos Jerjes-Sánchez and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-26 with Medical categories.

This book provides an up-to-date review of the use of thrombolytic therapy in the treatment of acute pulmonary embolism. It discusses the mechanisms of thrombosis; pharmacokinetics and pharmacodynamics of the most commonly used fibrinolytics; evidence-based results from multicenter control trials in which thrombolytic treatment was administered; criteria by which pulmonary embolism patients requiring thrombolysis are identified; and the use of thrombolytic therapy in special situations such as in in-transit thrombus and pregnancy. Focusing on peripheral intravenous thrombolysis, which can performed safely and effectively in emergency departments, hospital wards, and intensive critical care units in tertiary and community hospitals, Thrombolysis in Pulmonary Embolism is a valuable resource for cardiologists, pulmonologists, and internists.

Practical Peripheral Arterial Thrombolysis

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Author : Jonothan J. Earnshaw
language : en
Publisher: Butterworth-Heinemann
Release Date : 1994

Practical Peripheral Arterial Thrombolysis written by Jonothan J. Earnshaw and has been published by Butterworth-Heinemann this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.

Thrombolytic Therapy In Acute Ischemic Stroke

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Author : Werner Hacke
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Thrombolytic Therapy In Acute Ischemic Stroke written by Werner Hacke and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

During the last decade scientists in both basic and clinical research have renew ed their interest in the potential role of thrombolytic therapy in the treatment of acute ischemic stroke. The reevaluation of this approach was kindled by our growing knowledge of the pathogenesis of thrombotic and embolic stroke and by the development of new thrombolytic agents. With no proven therapy for acute ischemic stroke available, the potential value of early pharmacologic recanalization of occluded vessels in the management of acute stroke patients - an approach that has been supported by animal experiments and a limited number of uncontrolled clinical pilot studies - is again under scrutiny. A sym posium on "Thrombolysis in Acute Cerebral Ischemia" was held in Heidel berg, Germany, in May 1990 to summarize and discuss the pathophysiological background for thrombolysis in acute ischemic stroke and the recent ex perimental and clinical experience with the new generation of thrombolytic agents. The editors are fortunate to be able to include authoritative manuscripts from almost all the speakers at the symposium. These include reports of work by the most active investigators in this challenging field. The editors wish to express their gratitude to all the contributors for the additional work they have undertaken. Additionally, we would like to thank Springer-Verlag, Heidelberg, for its generous assistance in the preparation and rapid publication of this volume. Heidelberg, August 1990 WERNER HACKE GREGORY J. DEL ZopPO MATTHIAS HIRSCHBERG Contents I.

Thrombolytic Therapy In Acute Ischemic Stroke Ii

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Author : Gregory J. DelZoppo
language : en
Publisher: Springer
Release Date : 1993

Thrombolytic Therapy In Acute Ischemic Stroke Ii written by Gregory J. DelZoppo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medical categories.

Over the last decade, interest in treatment of ischemic stroke has increased significantly. Perhaps the single most important feature of attempts to improve the outcome of stroke patients has been that the interventions be applied within the very early hours of stroke symptoms. This has spawned efforts to understand the vascular and neuronal responses to cerebral artery reperfusion experimentally. Important prospective clinical studies of thrombolysis in acute ischemic stroke have been completed, and large placebo-controlled, symptom-based studies are now underway worldwide. Here, we consider the central features of those studies, their experimental basis, and the future importance of adjunctive therapies to recanalization in focal brain ischemia acutely. Risks and benefits are discussed. This collection benefits from the opinions of experts and workers in this rapidly evolving and exciting field.

Textbook Of Coronary Thrombosis And Thrombolysis

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Author : R. C. Becker
language : en
Publisher: Springer Science & Business Media
Release Date : 1998-01-31

Textbook Of Coronary Thrombosis And Thrombolysis written by R. C. Becker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-01-31 with Medical categories.

Teleologically, the hemostatic mechanism is among The of Coronary Thrombosis and the most fundamental yet complex physiologic pro- in essence, represents a heartfelt gift of cesses in humans. Early scientists and physicians were knowledge from a dedicated group of scientists and fascinated by the blood's ability to remain in a liquid clinicians, who collectively have set out on a mission state only to clot in response to vascular injury. The to minimize the societal impact of"hemostasis in the cellular and noncellular components of normal wrong place. " The book is divided into four distinct hemostasis took centuries to discover, and the intrica- sections: Part 1, Scientific Principles, lays down the cies of their delicate interactions are still being unrav- supporting foundation; Part 2, Clinical Application eled today. As is so often the case, an in-depth of Scientific Principles, places the knowledge base in appreciation of physiologic hemostasis, representing a a working perspective, directly applying science to basic life-sustaining sequence of events, paved the patient care; Part 3, New Dimensions, provides a way for understanding abnormal hemostasis or glimpse of tomorrow. Steering the field clear of se- pathologic thrombosis. Aristotle, Malpighi, and proclaimed victory and the dangers of complacency as Osier, representing but a few of the founding fathers we move into the 21st century, Part 4, Evolution of in the field, would undoubtedly be honored to see Thrombocardiology, focuses on laboratory standards, their observations form the template for lifesaving clinical trials, and drugs in development.