Receptor And Ion Channel Trafficking

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Receptor And Ion Channel Trafficking

Receptor And Ion Channel Trafficking written by Stephen John Moss and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Ion channels categories.

Receptor And Ion Channel Trafficking

Receptor And Ion Channel Trafficking written by Stephen John Moss and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medical categories.

A volume in the Molecular and Cellular Neurobiology series.This book reviews the recent advances in our understanding of the molecular and cellular mechanisms that control the assembly, transport, targeting and anchoring of the protein complexes making up the most important ion channels and receptor families, fundamental to synaptic function. Improved understanding of these processes is expected to reveal novel therapeutic targets relevant to a range of disease states.The first section of the book contains three chapters dealing with cation channels and provides an accessible, succinct and comprehensive account of what is known about the structures and the assembly and targeting of these multimeric proteins. The focus of the book then moves on to cover ligand-gated ion channels with two chapters on acetylcholine receptors. The final section of the book contains four chapters covering the excitatory and inhibitory amino acid receptors. Receptor and Ion-Channel Trafficking provides an integrated overview of the significant recent advances in the field of molecular neurobiology and will be essential reading for all researchers in neuroscience, neurobiology, biochemistry, cellular and molecular biology.

The Role Of Psd 95 In Ampa Receptor Clustering And Synaptic Plasticity

The Role Of Psd 95 In Ampa Receptor Clustering And Synaptic Plasticity written by Eric Schnell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.

Transactions

Transactions written by Biochemical Society (Great Britain) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Biochemistry categories.

Molecular Determinants Of Atp Binding To P2x2 Ion Channels

Molecular Determinants Of Atp Binding To P2x2 Ion Channels written by Shlomo S. Dellal and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Adenosine categories.

Biochemistry And Cell Biology

Biochemistry And Cell Biology written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Biochemistry categories.

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Journal Of Cell Science written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.

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Molecular Biology Of The Cell written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Cells categories.

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Trafficking Of Cardiac Ion Channels

Trafficking Of Cardiac Ion Channels written by Marcel Verges and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-27 with Science categories.

Protein sorting and trafficking are regulated by well-conserved mechanisms. These allow a distinctive set of resident proteins to be present in the correct subcellular organelle, which is required for proper cell functioning. Voltage-gated ion channels, as responsible for cardiomyocyte action potential, must be properly localized. They participate in cell excitability and electrical coupling, ensuring uninterrupted and rhythmic heart beating. Ion channel complexes comprise one or more pore-forming α subunits, associated β subunits, and additional proteins. Channel localization and function are regulated by the β subunits and associated proteins, such as cytoskeletal elements, cell-adhesion molecules, and adaptors. These influence protein targeting, anchoring, and retention in specific surface domains along the cardiomyocyte sarcolemma, such as intercalated discs, T-tubules, or the lateral membrane. Alterations in ion channel trafficking are the cause of channelopathies associated with inherited arrhythmias leading to sudden death. An outstanding question is how these molecular alterations lead to disease. In this volume, scientists share their vision to understand how cardiac ion channel trafficking is regulated and how it may become altered, leading to channelopathies that often turn into deadly arrhythmias. Data generated can be translated to a clinical context, hopefully turning into approaches to help prevention and treatment, which is of utmost importance, both medically and socially.