Proteins At Interfaces

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Proteins At Interfaces

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Author : John L. Brash
language : en
Publisher:
Release Date : 1987

Proteins At Interfaces written by John L. Brash and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Science categories.

Proteins At Interfaces

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Author : Florian Evers
language : en
Publisher:
Release Date : 2010

Proteins At Interfaces written by Florian Evers and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.

Protein Instability At Interfaces During Drug Product Development

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Author : Jinjiang Li
language : en
Publisher: Springer
Release Date : 2022-02-13

Protein Instability At Interfaces During Drug Product Development written by Jinjiang Li and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-13 with Medical categories.

Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas.

Proteins At Interfaces Ii

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Author :
language : en
Publisher:
Release Date : 1995

Proteins At Interfaces Ii written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.

Proteins At Solid Liquid Interfaces

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Author : Philippe Déjardin
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-09-28

Proteins At Solid Liquid Interfaces written by Philippe Déjardin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-09-28 with Science categories.

This book opens with a description of fundamental aspects of protein adsorption to surfaces, a phenomenon that plays a key role in biotechnological applications, especially at solid-liquid interfaces. Presented here are methods for studying adsorption kinetics and conformational changes such as optical waveguide lightmode spectroscopy (OWLS). Also described are sensitive bench techniques for measuring the orientation and structure of proteins at solid-liquid interfaces, including total internal reflection ellipsometry (TIRE), dual polarisation interferometry (DPI) and time of flight - secondary ion mass spectrometry (TOF–SIMS). A model study of fibronectin at polymer surfaces is included, as are studies using microporous membranes and textiles with immobilized enzymes for large-scale applications. Biocompatibility, anti-fouling properties and surface modification to modulate the adsorption and activity of biomolecules are among the other topics addressed in this invaluable book.

Proteins At Liquid Interfaces

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Author : D. Möbius
language : en
Publisher: Elsevier
Release Date : 1998-04-24

Proteins At Liquid Interfaces written by D. Möbius and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-04-24 with Science categories.

The interfacial behaviour of surfactants and proteins, and their mixtures, is of importance in a wide range of areas such as food technology, detergency, cosmetics, coating processes, biomedicine, pharmacy and biotechnology. Methods such as surface and interfacial tension measurements and interfacial dilation and shear rheology characterise the relationships between these interfacial properties and the complex behaviour of foams and emulsions is established. Recently-developed experimental techniques, such as FRAP which enable the measurement of molecular mobility in adsorption layers, are covered in this volume. The development of theories to describe the thermodynamic surface state or the exchange of matter for proteins and protein/surfactant mixtures is also described.Features of this book:• Reflects the state-of-the-art research and application of protein interfacial layers rather than a snapshot of only some recent developments.• Emphasis is placed on experimental details as well as recent theoretical developments.• New experimental techniques applied to protein interfacial layers are described, such as FRAP or ADSA, or rheological methods to determine the mechanical behaviour of protein-modified interfaces.• A large number of practical applications, ranging from emulsions relevant in food technology for medical problems such as lung surfactants, to the characterisation of foams intrinsic to beer and champagne production.The book will be of interest to research and university institutes dedicated to interfacial studies in chemistry, biology, pharmacy, medicine and food engineering. Industrial departments for research and technology in food industry, pharmacy, medicine and brewery research will also find this volume of value.

Proteins At Interfaces

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Author :
language : en
Publisher:
Release Date : 19??

Proteins At Interfaces written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 19?? with categories.

Surface And Interfacial Aspects Of Biomedical Polymers Vol 2 Protein Adsorption

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Author : Joseph Andrade
language : en
Publisher: Springer
Release Date : 1985

Surface And Interfacial Aspects Of Biomedical Polymers Vol 2 Protein Adsorption written by Joseph Andrade and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Science categories.

Structure And Plasticity Of Protein Protein Interfaces In Factor Xa And The Androgen Receptor

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Author : Eugene Hur
language : en
Publisher:
Release Date : 2006

Structure And Plasticity Of Protein Protein Interfaces In Factor Xa And The Androgen Receptor written by Eugene Hur and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.

To better understand these issues in the context of the proteolytic blood coagulation cascade, the structure of factor Xa (FXa) was solved in complex with a M84R variant of the macromolecular protease inhibitor ecotin. The structure reveals the atomic mechanism of association. Despite not possessing the recognition sequence of canonical FXa substrates, ecotin binds FXa with pico-molar affinity through a combination of induced fit and nonspecific secondary site interactions.

Efficient Characterization Of Protein Protein Interfaces Involved In Cellular Signaling

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Author : Michael Lloyd Reese
language : en
Publisher:
Release Date : 2006

Efficient Characterization Of Protein Protein Interfaces Involved In Cellular Signaling written by Michael Lloyd Reese and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.

In summary, I created a generalized methodology for efficient characterization of macromolecular complexes. Combining this with additional biophysical, biochemical, and genetic techniques in the study of various macromolecular complexes involved in neuronal plasticity and membrane trafficking has furthered our understanding of the molecular basis of signal transduction.