Organic Cation Transport

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Organic Cation Transport

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Author : Giuliano Ciarimboli
language : en
Publisher:
Release Date : 2007

Organic Cation Transport written by Giuliano Ciarimboli and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Carrier proteins categories.

Organic Cation Transporter 1 Oct1 Not Vital For Life But Of Substantial Biomedical Relevance

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Author : Jurgen Brockmoller
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-12

Organic Cation Transporter 1 Oct1 Not Vital For Life But Of Substantial Biomedical Relevance written by Jurgen Brockmoller and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-12 with Science categories.

Around one third of all biologically relevant small molecules are organic cations. These include endogenous substances like catecholamines and other neurotransmitters, toxins and drugs designed to affect signaling processes. The organic cation transporter 1 (OCT1) is among the strongest expressed membrane transporters at the sinusoidal (blood-facing) side of liver cells and contributes substantially to the clearance of the blood from numerous organic cations. A most striking feature of OCT1 is its pronounced genetic diversity. Between 1 and 10% of all human populations have little to no OCT1 activity. With several of the OCT1 substrates up to 10% of Europeans are functionally OCT1 deficient. Apparently, the lack of OCT1 do not lead to apparent substantial pathological changes in these individuals. It thus appears that this transporter is not essential to human life, but does it means that OCT1 is irrelevant? In the last 25 years since the first cloning of this transporter, data on its pharmacological and physiological relevance is steadily accumulating. Numerous clinically relevant drugs (e.g. metformin, morphine, fenoterol, sumatriptan, tramadol and tropisetron) have been shown to be substrates of OCT1, and OCT1 deficiency has been shown to affect the pharmacokinetics, efficacy, or toxicity of these drugs. Also vitamin B1 has been shown to be a substrate of OCT1, and in genetically modified mice OCT1 substantially modulated hepatic lipid metabolism, total body fat and systemic glucose and lipid concentrations. Still, numerous important questions remain unsolved: For which drugs, toxins, or other endogenous or exogenous substances is OCT1 relevant? How can we predict the relevance of OCT1 from in vitro studies? What determines the substrate selectivity of OCT1 in comparison to other transporters or transport processes for organic cations? What regulates the expression of OCT1 in the liver and possibly in other tissues? What is the impact of OCT1 variation in different areas of medicine, including the therapies for cancer as well as for pulmonary, cardiovascular, or neurological diseases? How can evolutionary biology contribute to a better understanding of the roles of OCT1? And, importantly, what types of research are likely to significantly further the knowledge on OCT1 in the next decades?

Organic Cation Transporters

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Author : Giuliano Ciarimboli
language : en
Publisher: Springer
Release Date : 2015-12-17

Organic Cation Transporters written by Giuliano Ciarimboli and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-17 with Medical categories.

This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues. This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.

Renal Organic Cation Transport

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Author : Adam Dudley
language : en
Publisher:
Release Date : 1996

Renal Organic Cation Transport written by Adam Dudley and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.

Organic Cation Transporters In The Central Nervous System

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Author : Lynette C. Daws
language : en
Publisher: Springer Nature
Release Date : 2021-10-27

Organic Cation Transporters In The Central Nervous System written by Lynette C. Daws and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-27 with Medical categories.

Rapidly growing interest in the role of organic cation transporters (OCTs) and plasma membrane monoamine transporter (PMAT) in central monoamine homeostasis makes this book especially timely, given its thematic alignment with the role of OCTs and PMAT in CNS. This book discusses latest insights into the field laying an emphasis on health, disease and therapeutics. The chapter, “General Overview of Organic Cation Transporters in Brain”, of this book is available open access under a CC BY 4.0 license at link.springer.com

Mechanism Of Organic Cation Transport In The Kidney

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Author : Paul P. Sokol
language : en
Publisher:
Release Date : 1986

Mechanism Of Organic Cation Transport In The Kidney written by Paul P. Sokol and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with categories.

Molecular Mechanisms Of Organic Cation Transport In Ephithelia

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Author : Lei Zhang
language : en
Publisher:
Release Date : 1998

Molecular Mechanisms Of Organic Cation Transport In Ephithelia written by Lei Zhang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Biological transport categories.

Renal Transport Of Cationic Drugs

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Author : Poe-Hirr Hsyu
language : en
Publisher:
Release Date : 1987

Renal Transport Of Cationic Drugs written by Poe-Hirr Hsyu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Cations categories.

Influence Of Substrate Structure On Organic Cation Transport Phd

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Author : Dallas Joesph Bednarczyk
language : en
Publisher:
Release Date :

Influence Of Substrate Structure On Organic Cation Transport Phd written by Dallas Joesph Bednarczyk and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.

Cellular And Molecular Characteristics Of Organic Cation Transport In Epithelia

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Author : Joanne K. Chun
language : en
Publisher:
Release Date : 1996

Cellular And Molecular Characteristics Of Organic Cation Transport In Epithelia written by Joanne K. Chun and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Cations categories.