Multivariate Data Integration Using R
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Multivariate Data Integration Using R
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Author : Kim-Anh Lê Cao
language : en
Publisher: CRC Press
Release Date : 2021-11-08
Multivariate Data Integration Using R written by Kim-Anh Lê Cao and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-08 with Mathematics categories.
Large biological data, which are often noisy and high-dimensional, have become increasingly prevalent in biology and medicine. There is a real need for good training in statistics, from data exploration through to analysis and interpretation. This book provides an overview of statistical and dimension reduction methods for high-throughput biological data, with a specific focus on data integration. It starts with some biological background, key concepts underlying the multivariate methods, and then covers an array of methods implemented using the mixOmics package in R. Features: Provides a broad and accessible overview of methods for multi-omics data integration Covers a wide range of multivariate methods, each designed to answer specific biological questions Includes comprehensive visualisation techniques to aid in data interpretation Includes many worked examples and case studies using real data Includes reproducible R code for each multivariate method, using the mixOmics package The book is suitable for researchers from a wide range of scientific disciplines wishing to apply these methods to obtain new and deeper insights into biological mechanisms and biomedical problems. The suite of tools introduced in this book will enable students and scientists to work at the interface between, and provide critical collaborative expertise to, biologists, bioinformaticians, statisticians and clinicians.
Rna Computational Methods For Structure Kinetics And Rational Design Volume One
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Author : Peter G. Clote
language : en
Publisher: CRC Press
Release Date : 2025-03-20
Rna Computational Methods For Structure Kinetics And Rational Design Volume One written by Peter G. Clote and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-20 with Computers categories.
Comprising two volumes, RNA: Computational Methods for Structure, Kinetics, and Rational Design is a comprehensive treatment of computational methods concerning the secondary structure, folding kinetics and rational design of RNA. Volume One concerns energy and structure and is divided into five chapters. Chapter 1 describes the molecular structure of ribonucleotides, basic classes of RNA and databases of RNA sequences and structure. Chapter 2 presents the basic concepts of thermodynamics, since thermodynamics-based algorithms constitute an essential tool in rational design of functional RNA molecules. Chapter 3 describes how empirical secondary structure energy parameters are obtained from ultraviolet absorbance experiments via Van 't Hoff plots and least-squares data fitting. Chapter 4 describes methods from combinatorics, automata and formal language theory, and complex analysis. Chapter 5 provides an overview of some of the most important thermodynamics-based algorithms related to secondary structure. Exercises and solutions are provided at the end of every chapter and source code is available at the book's website (sometimes including computer programs using Python and extensions Numpy and Scipy). This book provides the nuts, bolts and tools to take the next steps in computational RNA synthetic biology. It is perfect for advanced undergraduate, graduate and post-graduate readers having analytical interests and skills from areas such as physical chemistry, physics, mathematics, computer science, and statistics.
Systems Biology And Machine Learning Methods In Reproductive Health
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Author : Abhishek Sengupta
language : en
Publisher: CRC Press
Release Date : 2025-01-10
Systems Biology And Machine Learning Methods In Reproductive Health written by Abhishek Sengupta and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-10 with Computers categories.
Systems Biology and Machine Learning Methods in Reproductive Health is an innovative and wide-ranging book that discovers the synergetic combination of disciplines: systems biology and machine learning, with an application in the field of reproductive health. This book assembles the expertise of leading scientists and clinicians to present a compilation of cutting-edge techniques and case studies utilizing computational methods to elucidate intricate biological systems, elucidate reproductive pathways, and address critical issues in the fields of fertility, pregnancy, and reproductive disorders. Bringing science and data science together, this groundbreaking book provides scientists, clinicians, and students with a step-by-step guide to uncovering the complexities of reproductive health through cutting-edge computational tools.
Principles Of Computational Genomics
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Author : Paolo Provero
language : en
Publisher: CRC Press
Release Date : 2025-05-13
Principles Of Computational Genomics written by Paolo Provero and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-13 with Science categories.
The advent of high-throughput experimental assays, and in particular of next-generation sequencing, has revolutionized life sciences by enabling the generation of data at the scale of the whole genome. Extracting biologically useful or clinically actionable information from this data requires analytical methods quite different from the ones used to analyze low-throughput experimental results. The development of these methods is the goal of computational biology. Understanding the principles on which these methods are based is thus necessary for all students and researchers in life sciences. This book provides the conceptual framework needed to understand computational genomics enough to be able to follow the arguments in recent papers, or to collaborate with computational scientists in research projects. In particular, it introduces the mathematical and statistical basis of the methods in some depth. The main focus is on the analysis of next-generation-sequencing assays, both for the interpretation of the DNA sequence per se (sequence alignment, phylogenetic tree reconstruction, genetic variants) and for the study of gene regulation and epigenomics (gene expression, transcription factor binding, chromatin states, 3D structure of the genome). The final chapter discusses the associations of genetic variants with phenotypes and diseases, and their biological interpretation. Principles of Computational Genomics provides a solid foundation for understanding the many parts of computational genomics, including those not treated directly in the book. It will be of great benefit to students and researchers across the life sciences.
Bioinformatics
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Author : Hamid D. Ismail
language : en
Publisher: CRC Press
Release Date : 2023-06-29
Bioinformatics written by Hamid D. Ismail and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-29 with Computers categories.
This book contains the latest material in the subject, covering next generation sequencing (NGS) applications and meeting the requirements of a complete semester course. This book digs deep into analysis, providing both concept and practice to satisfy the exact need of researchers seeking to understand and use NGS data reprocessing, genome assembly, variant discovery, gene profiling, epigenetics, and metagenomics. The book does not introduce the analysis pipelines in a black box, but with detailed analysis steps to provide readers with the scientific and technical backgrounds required to enable them to conduct analysis with confidence and understanding. The book is primarily designed as a companion for researchers and graduate students using sequencing data analysis but will also serve as a textbook for teachers and students in biology and bioscience.
Computational Intelligence For Oncology And Neurological Disorders
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Author : Mrutyunjaya Panda
language : en
Publisher: CRC Press
Release Date : 2024-07-15
Computational Intelligence For Oncology And Neurological Disorders written by Mrutyunjaya Panda and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-15 with Computers categories.
With the advent of computational intelligence-based approaches, such as bio-inspired techniques, and the availability of clinical data from various complex experiments, medical consultants, researchers, neurologists, and oncologists, there is huge scope for CI-based applications in medical oncology and neurological disorders. This book focuses on interdisciplinary research in this field, bringing together medical practitioners dealing with neurological disorders and medical oncology along with CI investigators. The book collects high-quality original contributions, containing the latest developments or applications of practical use and value, presenting interdisciplinary research and review articles in the field of intelligent systems for computational oncology and neurological disorders. Drawing from work across computer science, physics, mathematics, medical science, psychology, cognitive science, oncology, and neurobiology among others, it combines theoretical, applied, computational, experimental, and clinical research. It will be of great interest to any neurology or oncology researchers focused on computational approaches.
Springer Handbook Of Chem And Bioinformatics
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Author : Jerzy Leszczynski
language : en
Publisher: Springer Nature
Release Date : 2025-12-31
Springer Handbook Of Chem And Bioinformatics written by Jerzy Leszczynski and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-12-31 with Science categories.
The Springer Handbook of Chem- and Bioinformatics provides an introduction as well as a detailed description of the application of various techniques used in chemo- and bioinformatics. It covers basic topics such as a discussion of computational techniques used in the predictions of structures, properties, and dynamics of small compounds, macromolecules, and their complexes. Diverse applications of QSAR methods are also revealed. Various chapters offer specifics of current methodologies used by research labs in the pharmaceutical industry for drug design. Modern computational approaches taking advantage of searching big data, using artificial intelligence and machine learning are discussed, while the necessity of applying such advanced novel techniques for bio- and chemo-informatics is revealed. This handbook combines nicely together discussion and assessment of both closely related fields of modern informatics. It is a welcome addition to the university libraries, research institutes, as well as to basic textbook resources of individual researchers. The target audience includes students (both graduate and advanced undergraduate), university researchers, scientists working in private and governmental laboratories as well as a large group of developers from pharmaceutical and medical institutes and related industrial research centers.
Bioinformatics Of Autoimmune Diseases
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Author : Hamid D. Ismail
language : en
Publisher: CRC Press
Release Date : 2026-02-12
Bioinformatics Of Autoimmune Diseases written by Hamid D. Ismail and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2026-02-12 with Science categories.
Autoimmune diseases arise when the immune system misidentifies the body’s own tissues as threats, a catastrophic failure of self-recognition that leads to chronic inflammation, tissue damage, and long-term disability. Bioinformatics of Autoimmune Diseases is a timely and comprehensive guide that explores not only the immunological basis of these disorders but also the cutting-edge bioinformatics approaches used to analyze the genomic, transcriptomic, and epigenomic data driving modern discovery. Structured to bridge foundational immunology with advanced computational analysis, this book offers readers a progression from the molecular mechanisms of immune function and dysfunction to the bioinformatics pipelines used to investigate them. Early chapters provide a thorough grounding in immune cell biology, immune checkpoints, and disease pathogenesis. Subsequent chapters guide readers through practical analyses of autoimmune disease data, covering RNA-Seq, variant analysis, microbiome profiling, ATAC-Seq, ChIP-Seq, single-cell sequencing, and gene therapy and autoimmune diseases. Bioinformatics tools are introduced using Python with step-by-step workflows, enabling hands-on engagement with real datasets. Written by a professor of bioinformatics and developer of bioinformatics tools, the book draws from over a decade of broad experience in computational biology. With detailed illustrations, curated datasets, and a clear emphasis on reproducibility, it serves as a foundational resource for graduate students, clinicians, biomedical researchers, and anyone seeking to decode the bioinformatics foundations and mechanisms driving autoimmune disease.
Proceedings International Symposium On Spatial Accuracy Of Natural Resource Data Bases
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Author : Russell G. Congalton
language : en
Publisher: American Society for Photogrammetry & Remote Sensing
Release Date : 1994
Proceedings International Symposium On Spatial Accuracy Of Natural Resource Data Bases written by Russell G. Congalton and has been published by American Society for Photogrammetry & Remote Sensing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Business & Economics categories.
Chemical Abstracts
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Author :
language : en
Publisher:
Release Date : 2002
Chemical Abstracts written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Chemistry categories.