Model Based Analysis Methods In Statistical Genomics

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Model Based Analysis Methods In Statistical Genomics

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Author :
language : en
Publisher:
Release Date : 2012

Model Based Analysis Methods In Statistical Genomics written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.

Model-based Analysis Methods in Statistical Genomics Qiuling He Under the supervision of Professor Michael A. Newton At the University of Wisconsin-Madison This thesis aims to solve two problems in statistical genomics: (1) how to model agreement among genome-wide RNA interference (RNAi) studies; and (2) how to integrate experimentally derived genomic data with functional annotations. The problems are distinct in their specific elements but share two important features: (1) solutions could have significant implications for the practice of statistical genomics, and (2) our approaches to solve them use common model-based tools and techniques. The RNAi analysis concerns four recent genome-wide studies of influenza virus replication. All studies identified genes whose inactivation alters a cell's ability to produce virus, and they all had a similar experimental design. In total 614 human genes were confirmed to have an affect on viral replication, however there were very limited agreement between the studies. For instance, only one gene was confirmed by all four studies. The apparent lack of agreement raises questions about the rate of false positives and false negatives in genome-wide RNAi. We develop a generative sampling model to describe the RNAi data, and with likelihood methods we use this model to assess the relative magnitude of false positive and false negative effects. The model accommodates many aspects of RNAi, but it is sufficiently simple that closed form inference summaries are available. Evidence points to a relatively high false negative rate. In the second part of the thesis, we investigate the problem of genomic data integration, specifically, the problem of integrating experimentally derived data with data on the known functional profiles of the annotated genes. Such functional category analysis is important to data reduction and for weak-signal identification, though state-of-the-art methodology does not adequately handle the complexity of growing systems of functional categories. We show that a leading model-based empirical Bayesian approach suffers inconsistency and inefficiency, and we propose a new approach to connect these problems.

Interactive Visualization And Model Based Analysis Of Genomics Data

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Author : Nameeta Yogeshkumar Shah
language : en
Publisher:
Release Date : 2006

Interactive Visualization And Model Based Analysis Of Genomics Data written by Nameeta Yogeshkumar Shah and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.

Journal Of The American Statistical Association

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Author :
language : en
Publisher:
Release Date : 2008

Journal Of The American Statistical Association written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Statistics categories.

Reconstruction And Systems Analysis Of Genome Scale Metabolic And Regulatory Networks In Saccharomyces Cerevisiae

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Author : Markus Juhana Herrgard
language : en
Publisher:
Release Date : 2004

Reconstruction And Systems Analysis Of Genome Scale Metabolic And Regulatory Networks In Saccharomyces Cerevisiae written by Markus Juhana Herrgard and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.

Encyclopedia Of Quantitative Risk Analysis And Assessment

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Author :
language : en
Publisher: Wiley
Release Date : 2008-09-02

Encyclopedia Of Quantitative Risk Analysis And Assessment written by and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-02 with Mathematics categories.

Leading the way in this field, the Encyclopedia of Quantitative Risk Analysis and Assessment is the first publication to offer a modern, comprehensive and in-depth resource to the huge variety of disciplines involved. A truly international work, its coverage ranges across risk issues pertinent to life scientists, engineers, policy makers, healthcare professionals, the finance industry, the military and practising statisticians. Drawing on the expertise of world-renowned authors and editors in this field this title provides up-to-date material on drug safety, investment theory, public policy applications, transportation safety, public perception of risk, epidemiological risk, national defence and security, critical infrastructure, and program management. This major publication is easily accessible for all those involved in the field of risk assessment and analysis. For ease-of-use it is available in print and online.

Genetic Analysis Of Complex Disease

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Author : Jonathan L. Haines
language : en
Publisher: Wiley-Liss
Release Date : 2006-05-05

Genetic Analysis Of Complex Disease written by Jonathan L. Haines and has been published by Wiley-Liss this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-05 with Medical categories.

Provides a comprehensive introduction to the various strategies, designs, and methods of analysis for the study of human genetic disease. It offers a broad-based understanding of the problems and solutions based on successful applications in the design and execution of gene mapping projects. Chapters present clear and easily referenced overviews of the broad range of considerations involved in genetic analysis of human genetic disease, including design, sampling, data collection, linkage and association studies, and social, legal, and ethical issues. Incorporating all new discussion questions and practical examples within each chapter, the book significantly updates treatment of bioinformatics, multiple comparisons, sample size requirements, parametric linkage analysis, case-control and family based approaches, and genomic screening. It covers new methods for analysis of gene-gene and gene-environmental interactions, and features a complete rewrite of the chapter on determining genetic components of disease.

Cornell University Courses Of Study

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Author : Cornell University
language : en
Publisher:
Release Date : 2007

Cornell University Courses Of Study written by Cornell University and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Universities and colleges categories.

Dissertation Abstracts International

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Author :
language : en
Publisher:
Release Date : 2008

Dissertation Abstracts International written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Dissertations, Academic categories.

Undergraduate And Graduate Courses And Programs

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Author : Iowa State University
language : en
Publisher:
Release Date : 2009

Undergraduate And Graduate Courses And Programs written by Iowa State University and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Universities and colleges categories.

Statistical Genetics

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Author : Benjamin M. Neale
language : en
Publisher: Taylor & Francis
Release Date : 2008

Statistical Genetics written by Benjamin M. Neale and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.

Statistical Genetics focuses on conducting genetic linkage and association analysis in the post-genomic era. It covers established and new methodologies, providing the genetic and statistical theory on which they are based. Worked examples of important methods are given, as well as study design and sources of error.