Microbial Proteomics
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Microbial Proteomics
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Author : Ian Humphery-Smith
language : en
Publisher: John Wiley & Sons
Release Date : 2006-08-28
Microbial Proteomics written by Ian Humphery-Smith and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-28 with Science categories.
Discover important lessons learned about whole organism biology via microbial proteomics This text provides an exhaustive analysis and presentation of current research in the field of microbial proteomics, with an emphasis on new developments and applications and future directions in research. The editors and authors show how and why the relative simplicity of microbes has made them attractive targets for extensive experimental manipulation in a quest for both improved disease prevention and treatment and an improved understanding of whole organism functional biology. In particular, the text demonstrates how microbial proteomic analyses can aid in drug discovery, including identification of new targets, novel diagnostic markers, and lead optimization. Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent and thorough approach throughout. Methods, technologies, and tools associated with the most promising approaches are stressed. Key topics covered include: Microbial pathogenesis at the proteome level Whole cell modeling Structural proteomics and computational analysis Biomolecular interactions Physiological proteomics Metabolic reconstruction using proteomics data While presenting the practical utility of proteomics data, the text is also clear on the field's current limitations, pointing to areas where further investigation is needed. Offering a state-of-the-art perspective from internationally recognized experts, this text is ideally suited for researchers and students across the gamut of genomic sciences, including biochemistry, microbiology, molecular biology, genetics, biomedical and pharmaceutical sciences, biotechnology, and veterinary science.
Microbial Proteomics Development In Technologies And Applications
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Author : Divakar Sharma
language : en
Publisher: Bentham Science Publishers
Release Date : 2020-12-31
Microbial Proteomics Development In Technologies And Applications written by Divakar Sharma and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-31 with Science categories.
This volume brings current knowledge of proteomics technologies and related developments with special reference to diseases caused by microbes. The editor has compiled chapters written by expert academicians which distill the information about useful methods in microbial proteomics for the benefit of readers. Chapters cover several methods used to investigate the microbial proteome and special topics such as antimicrobial drug resistance mechanisms, biomarker developments, post translational modifications. Key Features: -overview of several biochemical methods in proteomics -full-color, high quality images of the most frequent technologies and applications -concise, well organized, and didactic format -updates in basic applied information -bibliographic references -information on proteomics for tuberculosis treatment This reference work is intended for researchers seeking information on laboratory techniques applied in proteomics research and microbiology.
Mass Spectrometry For Microbial Proteomics
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Author : Haroun N. Shah
language : en
Publisher: John Wiley & Sons
Release Date : 2010-10-28
Mass Spectrometry For Microbial Proteomics written by Haroun N. Shah and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-28 with Science categories.
New advances in proteomics, driven largely by developments in mass spectrometry, continue to reveal the complexity and diversity of pathogenic mechanisms among microbes that underpin infectious diseases. Therefore a new era in medical microbiology is demanding a rapid transition from current procedures to high throughput analytical systems for the diagnosis of microbial pathogens. This book covers the broad microbiological applications of proteomics and mass spectrometry. It is divided into six sections that follow the general progression in which most microbiology laboratories are approaching the subject –Transition, Tools, Preparation, Profiling by Patterns, Target Proteins, and Data Analysis.
Microbial Proteomics
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Author : Dörte Becher
language : en
Publisher: Humana
Release Date : 2019-10-11
Microbial Proteomics written by Dörte Becher and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-11 with Science categories.
This detailed volume explores state-of-the-art methods for the identification, quantification, and characterization of microbial proteins. Split into five parts, the content addresses global sample preparation and protein enrichment, subcellular fractionation, protein quantification, analysis of post-translational protein modifications, as well as metaproteomics, a relatively new branch of microbial proteomics that investigates the proteins of all microbes comprising an environmental consortium. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Microbial Proteomics: Methods and Protocols serves as a valuable and stimulating source for all beginners and advanced researchers in the field of microbial proteomics and beyond. Chapter 18 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Microbial Proteomics
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Author : Divakar Sharma
language : en
Publisher:
Release Date : 2020-12-31
Microbial Proteomics written by Divakar Sharma and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-31 with categories.
This volume brings current knowledge of proteomics technologies and related developments with special reference to diseases caused by microbes. The editor has compiled chapters written by expert academicians which distill the information about useful methods in microbial proteomics for the benefit of readers. Chapters cover several methods used to investigate the microbial proteome and special topics such as antimicrobial drug resistance mechanisms, biomarker developments, post translational modifications.Key Features: -overview of several biochemical methods in proteomics-full-color, high quality images of the most frequent technologies and applications-concise, well organized, and didactic format-updates in basic applied information-bibliographic references-information on proteomics for tuberculosis treatmentThis reference work is intended for researchers seeking information on laboratory techniques applied in proteomics research and microbiology
Microbial Proteomics
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Author : Michael Hecker
language : en
Publisher:
Release Date : 2011
Microbial Proteomics written by Michael Hecker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Applications Of Genomics And Proteomics For Analysis Of Bacterial Biological Warfare Agents
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Author : Vito G. DelVecchio
language : en
Publisher:
Release Date : 2003
Applications Of Genomics And Proteomics For Analysis Of Bacterial Biological Warfare Agents written by Vito G. DelVecchio and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medical categories.
Applied Genomics And Proteomics
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Author :
language : en
Publisher:
Release Date : 2002
Applied Genomics And Proteomics written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Gene therapy categories.
Quantitative Proteomic And Transcriptomic Analyses Of The Responses Of Microorganisms And Microbial Communities To Environmental Stimuli
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Author : Christopher Phillip Belnap
language : en
Publisher:
Release Date : 2009
Quantitative Proteomic And Transcriptomic Analyses Of The Responses Of Microorganisms And Microbial Communities To Environmental Stimuli written by Christopher Phillip Belnap and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Proteomics Of Microbial Human Pathogens
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Author : Nelson C. Soares
language : en
Publisher: Frontiers Media SA
Release Date : 2017-01-17
Proteomics Of Microbial Human Pathogens written by Nelson C. Soares and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-17 with categories.
According to the World Health Organization (WHO), in 2012 infectious diseases and related conditions account for more than 70% of premature deaths across 22 African countries and estimated 450 000 people worldwide developed multi-drug resistant tuberculosis. This alarming situation, of great public health concern, calls for the urgent development of novel and efficient responding strategies. The employment of important research platforms, such as genomics and proteomics, has contributed significant insight into the mechanisms underlying microbial infection and microbe-host interaction. In this Frontiers Research Topic, we aim to produce a timely and pertinent discussion regarding the current status of “Proteomics of microbial Human pathogens” and the role of proteomics in combating the challenges posed by microbial infection and indeed acquired anti-microbial resistance. As the field of proteomics progressed from 2-DE gel based approaches to modern LC-MS/MS based workflows, remarkable advances have been reported in terms of data quantity and quality. Given the immediate and enormous advantages that high resolution and accurate mass spectrometers have brought to the field, proteomics has now evolved into a robust platform capable of generating large amounts of comprehensive data comparable to that reported previously in genomics studies. For example, detection of the complete yeast proteome has been reported and other small proteomes, such as those of bacteria, are within reach. Mass spectrometry-based proteomics has become an essential tool for biologists and biochemists, and is now considered by many as an essential component of modern structural biology. Additionally, the introduction of high-resolution mass spectrometers has driven the development of various different strategies aimed at accurate quantification of absolute and relative amount of protein(s) of interest. Emerging targeted mass spectrometry methodologies such as; Selected Reaction Monitoring (SRM), Parallel Reaction Monitoring (PRM) and SWATH, are perhaps the latest breakthrough within the proteomics community. Indeed, through a label free approach, targeted mass spectrometry offers an unequalled capability to characterize and quantify a specific set of proteins reproducibility, in any biological sample. Usefully, Aebersold and colleagues have recently generated and validated a number of assays to quantify 97% of the 4,012 annotated Mycobacterium tuberculosis (Mtb) proteins by SRM. As such, the Mtb Proteome library represents a valuable experimental resource that will undoubtedly bring new insight to the complex life cycle of Mtb. Finally, as reviewed recently in Frontiers Research Topic, mass spectrometry-based proteomics has had a tremendous impact on our current understanding of post translational modification (PTM) in bacteria including the key role of PTMs during interaction of pathogenic bacteria and host interactions. We believe that our understanding of microbial Human pathogens has benefited enormously from both 2-DE gel and modern LC-MS/MS based proteomics. It is our wish to produce an integrated discussion surrounding this topic to highlight the existing synergy between these research fields. We envisage this Research Topic as a window to expert opinions and perspectives on the realistic practicalities of proteomics as an important tool to address healthcare problems caused by microbial pathogens.