Macromolecular Crystallography

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Macromolecular Crystallography Protocols Volume 2

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Author : Sylvie Doublie
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-05

Macromolecular Crystallography Protocols Volume 2 written by Sylvie Doublie and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-05 with Science categories.

In the decade since publication of the first edition of Crystallographic Methods and Protocols the field has seen several major developments that have both accelerated the pace of structure determination and made crystallography accessible to a broader range of investigators. Volume I, Preparation and Crystallization of Macromolecules is dedicated to the crystallization and ways to increase the odds of obtaining crystals in macromolecules, while Volume 2, Structure Determination, covers both computational methods for characterizing crystals and solving structures.

Introduction To Macromolecular Crystallography

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Author : Alexander McPherson
language : en
Publisher: John Wiley & Sons
Release Date : 2011-09-20

Introduction To Macromolecular Crystallography written by Alexander McPherson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-20 with Science categories.

A comprehensive and approachable introduction to crystallography — now updated in a valuable new edition The Second Edition of this well-received book continues to offer the most concise, authoritative, and easy-to-follow introduction to the field of crystallography. Dedicated to providing a complete, basic presentation of the subject that does not assume a background in physics or math, the book's content flows logically from basic principles to methods, such as those for solving phase problems, interpretation of Patterson maps and the difference Fourier method, the fundamental theory of diffraction and the properties of crystals, and applications in determining macromolecular structure. This new edition includes a vast amount of carefully updated materials, as well as two completely new chapters on recording and compiling X-ray data and growing crystals of proteins and other macromolecules. Richly illustrated throughout to clarify difficult concepts, this book takes a non-technical approach to crystallography that is ideal for professionals and graduate students in structural biology, biophysics, biochemistry, and molecular biology who are studying the subject for the first time.

Macromolecular Crystallography

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Author : Mark R. Sanderson
language : en
Publisher: OUP Oxford
Release Date : 2007-08-23

Macromolecular Crystallography written by Mark R. Sanderson and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-23 with Science categories.

Macromolecular Crystallography is the study of macromolecules (proteins and nucleic acids) using X-ray crystallographic techniques in order to determine their molecular structure. The knowledge of accurate molecular structures is a pre-requisite for rational drug design, and for structure-based function studies to aid the development of effective therapeutic agents and drugs. The successful determination of the complete genome (genetic sequence) of several species (including humans) has recently directed scientific attention towards identifying the structure and function of the complete complement of proteins that make up that species; a new and rapidly growing field of study called 'structural genomics'. There are now several important and well-funded global initiatives in operation to identify all of the proteins of key model species. One of the main requirements for these initiatives is a high-throughput crystallization facility to speed-up the protein identification process. The extent to which these technologies have advanced, calls for an updated review of current crystallographic theory and practice. This practical reference book features the latest conventional and high-throughput methods, and includes contributions from a team of internationally recognized leaders and experts. It will be of relevance and use to graduate students, research scientists and professionals currently working in the field of conventional and high-throughput macromolecular crystallography.

Macromolecular Crystallography

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Author : Charles W. Carter
language : en
Publisher: Gulf Professional Publishing
Release Date : 2003

Macromolecular Crystallography written by Charles W. Carter and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Computer simulation categories.

Part A: This volume emphasizes the revision and extension of statistical tools that underly all phases of structure determination, the practical and conceptual impact of synchroton radiation, horizon phase-determination methods and computerized automation.

Macromolecular Crystallography

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Author : Charles W. Carter
language : en
Publisher:
Release Date : 1997

Macromolecular Crystallography written by Charles W. Carter and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Crystallography categories.

Macromolecular Crystallography

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Author : Maria Armenia Carrondo
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-12-01

Macromolecular Crystallography written by Maria Armenia Carrondo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-01 with Science categories.

This volume is a collection of the contributions presented at the 42nd Erice Crystallographic Course whose main objective was to train the younger generation on advanced methods and techniques for examining structural and dynamic aspects of biological macromolecules. The papers review the techniques used to study protein assemblies and their dynamics, including X-ray diffraction and scattering, electron cryo-electron microscopy, electro nanospray mass spectrometry, NMR, protein docking and molecular dynamics. A key theme throughout the book is the dependence of modern structural science on multiple experimental and computational techniques, and it is the development of these techniques and their integration that will take us forward in the future.

Evolving Methods For Macromolecular Crystallography

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Author : Randy J. Read
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-06-25

Evolving Methods For Macromolecular Crystallography written by Randy J. Read and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-25 with Computers categories.

This volume draws on the expertise of leaders in the field of macromolecular crystallography to illuminate the dramatic developments that are accelerating progress in structural biology. Their contributions span the range of techniques from crystallization through data collection, structure solution and analysis. The book shows how modern high-throughput methods are contributing to a deeper understanding of medical problems.

Macromolecular Crystallography Part A

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Author : Charles W. Carter
language : en
Publisher: Academic Press
Release Date : 1997-02-12

Macromolecular Crystallography Part A written by Charles W. Carter and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-02-12 with Medical categories.

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 270 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Crystal Growth Phase Determination Instrumentation and Data Collection Model Building Refinement

Macromolecular Crystallography With Synchrotron Radiation

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Author : John R. Helliwell
language : en
Publisher: Cambridge University Press
Release Date : 1992

Macromolecular Crystallography With Synchrotron Radiation written by John R. Helliwell and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Science categories.

This highly illustrated monograph provides a comprehensive treatment of the study of the structure and function of the molecules of life--proteins, nucleic acids, and viruses--using synchrotron radiation and crystallography. Beginning with chapters on the fundamentals of macromolecular crystallography and macromolecular structure, the book goes on to review the sources and properties of synchrotron radiation, instrumentation, and monochromatic data collection. There are also chapters on the Laue method, on diffuse X-ray scattering, and on variable wavelength anomalous dispersion methods. The book concludes with a description and survey of applications including studies at high resolution, the use of small crystals, the study of large unit cells, and time-resolved crystallography (particularly of enzymes). Appendices are provided that present essential information for the synchrotron user as well as information about synchrotron facilities currently available.

Macromolecular Crystallography Part D

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Author : Charles W. Carter Jr.
language : en
Publisher: Academic Press
Release Date : 2003-12-10

Macromolecular Crystallography Part D written by Charles W. Carter Jr. and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-12-10 with Business & Economics categories.

Accurate molecular structures is vital for rational drug design and for structure based functional studies directed toward the development of effective therapeutic agents and drugs. Crystallography can reliably predict structure, both in terms of folding and atomic details of bonding. * Phases * Map interpretation and refinement * Analysis and software