Heterogeneity In Statistical Genetics

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Heterogeneity In Statistical Genetics

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Author : Derek Gordon
language : en
Publisher: Springer Nature
Release Date : 2020-12-16

Heterogeneity In Statistical Genetics written by Derek Gordon and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-16 with Medical categories.

Heterogeneity, or mixtures, are ubiquitous in genetics. Even for data as simple as mono-genic diseases, populations are a mixture of affected and unaffected individuals. Still, most statistical genetic association analyses, designed to map genes for diseases and other genetic traits, ignore this phenomenon. In this book, we document methods that incorporate heterogeneity into the design and analysis of genetic and genomic association data. Among the key qualities of our developed statistics is that they include mixture parameters as part of the statistic, a unique component for tests of association. A critical feature of this work is the inclusion of at least one heterogeneity parameter when performing statistical power and sample size calculations for tests of genetic association. We anticipate that this book will be useful to researchers who want to estimate heterogeneity in their data, develop or apply genetic association statistics where heterogeneity exists, and accurately evaluate statistical power and sample size for genetic association through the application of robust experimental design.

Handbook Of Statistical Genetics

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Author : D. J. Balding
language : en
Publisher:
Release Date : 2001-03-28

Handbook Of Statistical Genetics written by D. J. Balding and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-03-28 with Mathematics categories.

A truly groundbreaking volume, the Handbook of Statistical Genetics is a timely, informative and highly accessible reference for both statisticians interested in genetical applications and geneticists seeking a deeper understanding of statistical methods in their field. It is divided into six main sections, encompassing the entire field of statistics in genetics: ? Bioinformatics ? Population Genetics ? Evolutionary Genetics ? Genetic Epidemiology ? Plant and Animal Genetics ? Applications As the Human Genome Project (HGP) reaches its climax, with the complete sequence of mankind, science is fast approaching an exciting new stage in its ability to understand genetic forces in man. In parallel to the HGP are major sequencing efforts in other organisms, enabling us to understand broader questions in evolution and classification. This explosion of data has led to an increased need for sophisticated statistical, mathematical and computational tools to enable complex data collection, analysis and interpretation of the results. ? Comprehensive coverage of the most pressing statistical issues in genetics. ? Offers a lucid introduction to newcomers, as well as providing invaluable information for more experienced researchers. ? Each chapter is written by a leading international authority from the field. ? Complemented by numerous examples, case studies, and references to useful resources on the web. This authoritative reference will be ideal for both students and researchers working in genetics, including statisticians, geneticists, molecular biologists, biochemists and computer scientists.

Journal Of The American Statistical Association

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Author :
language : en
Publisher:
Release Date : 2008

Journal Of The American Statistical Association written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Electronic journals categories.

Statistical Genetics

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Author : Benjamin M. Neale
language : en
Publisher: Taylor & Francis
Release Date : 2008

Statistical Genetics written by Benjamin M. Neale and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.

Statistical Genetics focuses on conducting genetic linkage and association analysis in the post-genomic era. It covers established and new methodologies, providing the genetic and statistical theory on which they are based. Worked examples of important methods are given, as well as study design and sources of error.

Convergent Issues In Genetics And Demography

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Author : Julian Adams
language : en
Publisher: Oxford University Press, USA
Release Date : 1990

Convergent Issues In Genetics And Demography written by Julian Adams and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Medical categories.

This volume provides up-to-date coverage of genetics and demography, fields that are closely related, but rarely combined. Now especially, they have many topics and approaches in common: the use of historical materials, a basic concern with heterogeneity, new models of vital rates with behavioral and biological components, theories for the interplay of genetic and demographic factors in the spread of disease. As a comprehensive survey of a fast-growing field, this will be a valuable source of information for a wide spectrum of professionals in genetics, population biology, biostatistics, social and economic demography, and anthropology.

Statistical Genetics

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Author : Prem Narain (Prof.)
language : en
Publisher:
Release Date : 1990

Statistical Genetics written by Prem Narain (Prof.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Science categories.

This Book Describes The Methodology Of A Field Of Biology That Weds Statistics And Genetics And Goes By The Name Of Statistical Genetics. The Relevant Principles Of Genetics, Statistics And Breeding Are Discussed Together At One Place. The Emphasis Is On The Important Applications Of The Statisticogenetic Principles To The Plant And Animal Breeding Problems. It Has Been Written For The Benefit Of Post- Graduate Students Majoring In The Fields Of Either Genetics And Breeding Or Statistics Applied To Agriculture. Also, Since Advanced Researches In This Field Which Have Taken Place Over The Years Are Scattered In Various Journals, This Book Is Equally Addressed To Researchers In The Fields Of Statistics, Genetics And Breeding.The Book Is Unique In Several Respects And Sets Itself Apart When Compared With Other Published Books On The Subject. The Basic Elements Of Mendelian Genetics Which Is Very Crucial To The Understanding Of The Subject Have Been Included Right In The Beginning. The Relevant Topics Of Population Genetics Essential For Understanding The Principles Of Quantitative Inheritance Have Also Been Dealt With. Special Treatment Has Been Given To The Topics Dealing With The Methods Of Selection And Crossbreeding Which Can Bring About Desired Genetic Improvement. Diallel And Partial Diallel Crosses, Both The Design As Well As The Analysis Aspects Have Been Included.Because Of The Inter-Disciplinary Nature Of The Subject, Bringinng In So To Say Biology And Mathematics Together, The Book Has Adopted An Integrated Approach Placing Due Emphasis On Both The Fields. Appropriate Mathematical And Statistical Derivations For Mathematically Oriented Readers As Also Concepts In Non- Mathematical Terms For Biologist Friends Have Been Presented In A Judicious Manner.

Proceedings Of The 5th World Congress On Genetics Applied To Livestock Production

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Author :
language : en
Publisher:
Release Date : 1994

Proceedings Of The 5th World Congress On Genetics Applied To Livestock Production written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Animal genetics categories.

Biostatistical Genetics And Genetic Epidemiology

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Author : Robert C. Elston
language : en
Publisher: John Wiley & Sons
Release Date : 2002-04-22

Biostatistical Genetics And Genetic Epidemiology written by Robert C. Elston and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-04-22 with Mathematics categories.

This is the third in a series of books based on articles from the Encyclopedia of Biostatistics. The editors have updated the articles from the Human Genetics section of the EoB, have adpated other articles to give them a genetic feel, and have included a number of newly commissioned articles.

Genetics Abstracts

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Author :
language : en
Publisher:
Release Date : 1998

Genetics Abstracts written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Genetics categories.

Journal Of The Indian Society Of Agricultural Statistics

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Author : Indian Society of Agricultural Statistics
language : en
Publisher:
Release Date : 2004

Journal Of The Indian Society Of Agricultural Statistics written by Indian Society of Agricultural Statistics and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Agriculture categories.

Includes articles along with Society's activities.