Genome Stability
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Genome Stability
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Author : Igor Kovalchuk
language : en
Publisher: Academic Press
Release Date : 2016-09-03
Genome Stability written by Igor Kovalchuk and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-03 with Science categories.
Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species. Genome Stability teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments. Genome Stability covers a wide range of topics, including the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes and mammals. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability as well as changes in genome stability in response to aging. Finally, Genome Stability covers how epigenetic factors contribute to genome stability and how the species pass the memory of the encounters to the progeny, thus influencing the genome of the progeny in an indirect manner. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly-expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. - Includes a collection of chapters on genome stability research from various kingdoms, including topics such as epigenetics and transgenerational effects - Provides the first comprehensive coverage of the differences in the mechanisms utilized by different organisms to maintain genomic stability - Contains applications of genome instability and its effect on human diseases - Explains how various species maintain the fine balance in genome stability and genome diversification in response to their environments
Genome Stability
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Author : Igor Kovalchuk
language : en
Publisher: Academic Press
Release Date : 2021-07-17
Genome Stability written by Igor Kovalchuk and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-17 with Science categories.
Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. - A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects - Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability - Contains applications of genome instability research and outcomes for human disease - Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair
Genome Stability And Human Diseases
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Author : Heinz-Peter Nasheuer
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-11
Genome Stability And Human Diseases written by Heinz-Peter Nasheuer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-11 with Medical categories.
Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting ‘bottlenecks’ in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations. This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader.
Genome Stability
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Author : James Haber
language : en
Publisher: Garland Science
Release Date : 2013-12-16
Genome Stability written by James Haber and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-16 with Science categories.
Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An overview of the four major pathways of homologous recombinational repair is followed by a description of the several mechanisms of nonhomologous end-joining. Designed as a textbook for advanced undergraduate and graduate students with a molecular biology and genetics background, researchers and practitioners, especially in cancer biology, will also appreciate the book as a reference.
Nuclear Genome Stability Dna Replication Telomere Maintenance And Dna Repair
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Author : Maria Isabel Nogueira Cano
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-09
Nuclear Genome Stability Dna Replication Telomere Maintenance And Dna Repair written by Maria Isabel Nogueira Cano and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-09 with Science categories.
Dna Damage Genome Stability And Human Disease
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Author : Yuejin Hua
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-27
Dna Damage Genome Stability And Human Disease written by Yuejin Hua and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-27 with Science categories.
Roles For The Saccharomyces Cerevisiae Mlh1 Mismatch Repair Gene In Genome Stability And Genetic Recombination
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Author : Juan Argueso Almeida
language : en
Publisher:
Release Date : 2004
Roles For The Saccharomyces Cerevisiae Mlh1 Mismatch Repair Gene In Genome Stability And Genetic Recombination written by Juan Argueso Almeida and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Genome Research
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Author :
language : en
Publisher:
Release Date : 2005
Genome Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Genetics categories.
Mobile Genetic Elements In Cellular Differentiation Genome Stability And Cancer
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Author : Tammy A. Morrish
language : en
Publisher: Frontiers Media SA
Release Date : 2018-01-16
Mobile Genetic Elements In Cellular Differentiation Genome Stability And Cancer written by Tammy A. Morrish and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-16 with categories.
The human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons, and mobilize by a “copy and paste” mechanism that relies of the presence of a functional reverse transcriptase activity. The extent to which these different types of elements are actively mobilizing varies among organisms, as revealed with the advent of Next Generation DNA sequencing (NGS). To understand the normal and aberrant mechanisms that impact the mobility of these elements requires a more extensive understanding of how these elements interact with molecular pathways of the cell, including DNA repair, recombination and chromatin. In addition, epigenetic based-mechanisms can also influence the mobility of these elements, likely by transcriptional activation or repression in certain cell types. Studies regarding how mobile genetic elements interface and evolve with these pathways will rely on genomic studies from various model organisms. In addition, the mechanistic details of how these elements are regulated will continue to be elucidated with the use of genetic, biochemical, molecular, cellular, and bioinformatic approaches. Remarkably, the current understanding regarding the biology of these elements in the human genome, suggests these elements may impact developmental biology, including cellular differentiation, neuronal development, and immune function. Thus, aberrant changes in these molecular pathways may also impact disease, including neuronal degeneration, autoimmunity, and cancer.
Maintaining Genome Stability The Role Of Helicases And Deaminases
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Author :
language : en
Publisher:
Release Date : 2008
Maintaining Genome Stability The Role Of Helicases And Deaminases written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Both helicases and deaminases are enzymes that play an important role in maintaining genomic stability and immune responses. Errors in duplicating DNA can result in genomic instability, leading to various human diseases, such as cancer, immune system disorder, muscle dystrophy, and neurodegenerations. Thus, maintaining genomic integrity is vital to the normal growth of cells and to human health. Maintenance of genome integrity during S phase depends in part on the activity and regulation of the replication enzymes, including replicative helicase called the MCM complex to preserve the genetic information. In contrast, deliberate errors are introduced during maturation of the immune system by modifying enzymes called deaminases. The cells response to different forms of damage is fundamental to its ability to repair itself when challenged by environmental or chemical insults. The goal of this proposal is to investigate mechanisms of genome integrity in cells using a combined genetic, biochemical, and structural approaches. These studies are highly relevant to understanding the development of cancer, including leukemias and breast cancer.