Drug Discovery And Development E Book

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Drug Discovery And Development E Book

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Author : Raymond G Hill
language : en
Publisher: Elsevier Health Sciences
Release Date : 2012-07-20

Drug Discovery And Development E Book written by Raymond G Hill and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-20 with Medical categories.

The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries' trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market. - The definitive introduction to how a pharmaceutical company goes about its business of discovering and developing drugs. The second edition has a new editor: Professor Raymond Hill ● non-executive director of Addex Pharmaceuticals, Covagen and of Orexo AB ● Visiting Industrial Professor of Pharmacology in the University of Bristol ● Visiting Professor in the School of Medical and Health Sciences at the University of Surrey ● Visiting Professor in Physiology and Pharmacology at the University of Strathclyde ● President and Chair of the Council of the British Pharmacological Society ● member of the Nuffield Council on Bioethics and the Advisory Council on Misuse of Drugs. New to this edition: - Completely rewritten chapter on The Role of Medicinal Chemistry in the Drug Discovery Process. - New topic - DMPK Optimization Strategy in drug discovery. - New chapter on Scaffolds: Small globular proteins as antibody substitutes. - Totally updated chapters on Intellectual Property and Marketing - 50 new illustrations in full colour Features - Accessible, general guide to pharmaceutical research and development. - Examines the interfaces between cost and social benefit, quality control and mass production, regulatory bodies, patent management, and all interdisciplinary intersections essential to effective drug development. - Written by a strong team of scientists with long experience in the pharmaceutical industry. - Solid overview of all the steps from lab bench to market in an easy-to-understand way which will be accessible to non-specialists. From customer reviews of the previous edition: '... it will have everything you need to know on this module. Deeply referenced and, thus, deeply reliable. - Highly Commended in the medicine category of the BMA 2006 medical book competition - Winner of the Royal Society of Medicine Library Prize for Medical Book of the Year

Basic Principles Of Drug Discovery And Development

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Author : Benjamin E. Blass
language : en
Publisher: Elsevier
Release Date : 2015-04-24

Basic Principles Of Drug Discovery And Development written by Benjamin E. Blass and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-24 with Medical categories.

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property." - Provides a clear explanation of how the pharmaceutical industry works - Explains the complete drug discovery process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual propertyIdeal for anyone interested in learning about the drug discovery process and those contemplating careers in the industry - Explains the transition process from academia or other industries

The Process Of New Drug Discovery And Development

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Author : Charles Giles Smith
language : en
Publisher:
Release Date : 1992

The Process Of New Drug Discovery And Development written by Charles Giles Smith and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Drugs categories.

Basic Principles Of Drug Discovery And Development

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Author : Benjamin E. Blass
language : en
Publisher:
Release Date : 2015

Basic Principles Of Drug Discovery And Development written by Benjamin E. Blass and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Drug development categories.

Clearly explains the complete drug discovery and development process from a multidisciplinary standpoint.

The Process Of New Drug Discovery And Development

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Author : G. Smith Charles
language : en
Publisher: CRC Press
Release Date : 1992-08-24

The Process Of New Drug Discovery And Development written by G. Smith Charles and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-08-24 with Medical categories.

The Process of New Drug Discovery and Development presents a practical methodology for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It includes detailed discussions regarding the research process and presents critiques of the governmental regulatory aspects of pharmaceutical research. The author also addresses the controversy surrounding the use of animals in biomedical research and provides current information regarding the field of biotechnology, international drug research, and registration activities. The Process of New Drug Discovery and Development is an excellent "how to" text for pharmaceutical researchers, oncologists, biochemists, experimental biologists, and others involved in new drug research and development.

Successful Drug Discovery Volume 5

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Author : János Fischer
language : en
Publisher: John Wiley & Sons
Release Date : 2021-02-03

Successful Drug Discovery Volume 5 written by János Fischer and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-03 with Medical categories.

Filled with unique insights into current drugs that have made it to the marketplace In the fifth volume of Successful Drug Discovery, the inventors and primary developers of drugs that made it to the market tell the story of the drugs discovery and development. Case studies of drugs from different therapeutic fields reveal the all-too-often unpredictable path from the first drug candidate molecule to the successfully marketed drug. In addition, this new volume addresses overarching topics for drug discovery, such as drug discovery in academia, and discusses currently important classes of small molecule as well as biological drugs. Comprehensive in scope, the books nine chapters provide a representative cross-section of the present-day drug development effort. The authoritative fifth volume is filled with relevant data and chemical information, as well as the insight and experience of the best contemporary drug creators. This important volume: - Puts the focus on recently introduced drugs that have not yet made it into standard textbooks or general references - Contains information and insight that is new and often not even available from the primary literature - Reveals what it takes to successfully develop a drug molecule that has made it all the way to the market - Is endorsed and supported by the International Union of Pure and Applied Chemistry (IUPAC) Written for medicinal chemists, pharmaceutical chemists, organic chemists, Successful Drug Discovery, Volume Five reveals the most recent techniques used by drug innovators in the drug development process.

Drug Discovery And Clinical Research

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Author : SK Gupta
language : en
Publisher: JP Medical Ltd
Release Date : 2011-06

Drug Discovery And Clinical Research written by SK Gupta and has been published by JP Medical Ltd this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06 with Medical categories.

The Drug Discovery and Clinical Research bandwagon has been joined by scientists and researchers from all fields including basic sciences, medical sciences, biophysicists, biotechnologists, statisticians, regulatory officials and many more. The joint effort and contribution from all is translating into the fast development of this multi-faceted field. At the same time, it has become challenging for all stakeholders to keep abreast with the explosion in information. The race for the finish-line leaves very little time for the researchers to update themselves and keep tabs on the latest developments in the industry. To meet these challenges, this book entitled Drug Discovery and Clinical Research has been compiled. All chapters have been written by stalwarts of the field who have their finger on the pulse of the industry. The aim of the book is to provide succinctly within one cover, an update on all aspects of this wide area. Although each of the chapter dealt here starting from drug discovery and development, clinical development, bioethics, medical devices, pharmacovigilance, data management, safety monitoring, patient recruitment, etc. are topics for full-fledged book in themselves, an effort has been made via this book to provide a bird’s eye view to readers and help them to keep abreast with the latest development despite constraints of time. It is hoped that the book will contribute to the growth of readers, which should translate into drug discovery and clinical research industry’s growth.

The Process Of New Drug Discovery And Development Second Edition

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Author : Charles G. Smith
language : en
Publisher: CRC Press
Release Date : 2006-06-23

The Process Of New Drug Discovery And Development Second Edition written by Charles G. Smith and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-23 with Medical categories.

The Process of New Drug Discovery and Development, Second Edition presents a practical methodology and up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. This new addition updates the scientific advances in new drug discovery and development for areas such as combinatorial chemistry, screening technologies, metabonomics, biotechnology approaches and preclinical testing. It also greatly expands the focus on the business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development, such as the financial aspects of starting up a pharmaceutical enterprise, the regulatory process, liability and litigation, and patent law.

Basic And Clinical Pharmacology 12 E Inkling Enhanced Ebook

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Author : Bertram G. Katzung
language : en
Publisher: McGraw Hill Professional
Release Date : 2012-03-22

Basic And Clinical Pharmacology 12 E Inkling Enhanced Ebook written by Bertram G. Katzung and has been published by McGraw Hill Professional this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-22 with Medical categories.

The most up-to-date, comprehensive, and authoritative pharmacology text in health medicine Enhanced by more than three hundred illustrations -- many in full color Organized to reflect the syllabi in many pharmacology courses and in integrated curricula, Basic & Clinical Pharmacology, 12e covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. Selection of the subject matter and order of its presentation are based on the authors’ many years experience in teaching this material to thousands of medical, pharmacy, dental, podiatry, nursing, and other health science students. To be as clinically relevant as possible, the book includes sections that specifically address the clinical choice and use of drugs in patients and the monitoring of their effects, and case studies that introduce clinical problems in many chapters. Presented in full color and enhanced by more than three hundred illustrations, Basic & Clinical Pharmacology features numerous summary tables and diagrams that encapsulate important information. Coverage that spans every aspect of medical pharmacology: Basic principles Autonomic drugs Cardiovascular-renal drugs Drugs with important actions on smooth muscles Central nervous system drugs Drugs used to treat anemias, clotting disorders, hyperlipidemia, and inflammation and gout Endocrine drugs Chemotherapeutic and immunologic drugs Toxicology Special subjects (perinatal, geriatric, and dermatologic pharmacology) Botanical and "food supplements," and over-the-counter medications Prescribing Also in this edition: Drug Summary Tables conclude most chapters, providing a concise summary of the most important drugs General concepts relating to newly discovered receptors, receptor mechanisms, and drug transporters Descriptions of important new drugs, including monoclonal antibodies

Social Aspects Of Drug Discovery Development And Commercialization

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Author : Odilia Osakwe
language : en
Publisher: Academic Press
Release Date : 2016-02-18

Social Aspects Of Drug Discovery Development And Commercialization written by Odilia Osakwe and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-18 with Medical categories.

Social Aspects of Drug Discovery, Development and Commercialization provides an insightful analysis of the drug discovery and development landscape as it relates to society. This book examines the scientific, legal, philosophical, economic, political, ethical and cultural factors that contribute to drug development. The pharmaceutical industry is under scrutiny to develop safer and more effective drugs in a quicker and more affordable manner. Recent criticism and debates have emphasized varying opinions on the issues concerning the drug discovery and development process. This book provides thoughtful and valuable discussions and analysis of the social challenges and potential opportunities through all stages of the pharmaceutical process, from inception through marketing. With a unique focus on the social factors that increasingly play a role in how drug development is planned, structured, and executed throughout the drug product lifecycle, this is an essential resource for students, professors, and researchers who seek a better understanding of the interface between the pharmaceutical industry, health care systems, and society. - Organized in a sequence of interrelated theories and principles that provide the foundation for increased understanding of the relevant social aspects - Includes analysis of important new advances, key scientific and strategic issues, and overviews of recent progress in drug development - Provides a global perspective with examples from developed areas, such as the US, Japan, Canada and Europe, as well as faster-growing and emerging economies including Brazil, Russia, India, and China - Serves as an essential resource for students, professors, and researchers who seek a better understanding of the interface between the pharmaceutical industry, health care systems, and society