Computational Exome And Genome Analysis

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Computational Exome And Genome Analysis

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Author : Peter N. Robinson
language : en
Publisher: CRC Press
Release Date : 2017-09-13

Computational Exome And Genome Analysis written by Peter N. Robinson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-13 with Computers categories.

Exome and genome sequencing are revolutionizing medical research and diagnostics, but the computational analysis of the data has become an extremely heterogeneous and often challenging area of bioinformatics. Computational Exome and Genome Analysis provides a practical introduction to all of the major areas in the field, enabling readers to develop a comprehensive understanding of the sequencing process and the entire computational analysis pipeline.

Computational Exome And Genome Analysis

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Author : Peter Nicholas Robinson
language : en
Publisher: Chapman & Hall/CRC Mathematical and Computational Biology
Release Date : 2017

Computational Exome And Genome Analysis written by Peter Nicholas Robinson and has been published by Chapman & Hall/CRC Mathematical and Computational Biology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Computational biology categories.

Cover -- Half Title -- Series Editor -- Published Titles -- Title -- Copyright -- Dedication -- Contents -- Who is this book for? -- Preface -- Contributors -- Part I Introduction -- Chapter 1 Introduction: Whole Exome and Genome Sequencing -- Chapter 2 NGS Technology -- Chapter 3 Illumina Technology -- Chapter 4 Data -- Part II Raw Data Processing -- Chapter 5 FASTQ Format -- Chapter 6 Raw Data: Quality Control -- Chapter 7 Trimming -- Part III Alignment -- Chapter 8 Alignment: Mapping Reads to the Reference Genome -- Chapter 9 SAM/BAM Format -- Chapter 10 Postprocessing the Alignment -- Chapter 11 Alignment Data: Quality Control -- Part IV Variant Calling -- Chapter 12 Variant Calling and Quality- Based Filtering -- Chapter 13 Variant Call Format (VCF) -- Chapter 14 Jannovar -- Chapter 15 Variant Annotation -- Chapter 16 Variant Calling: Quality Control -- Chapter 17 Integrative Genomics Viewer (IGV): Visualizing Alignments and Variants -- Chapter 18 De Novo Variants -- Chapter 19 Structural Variation -- Part V Variant Filtering -- Chapter 20 Pedigree and Linkage Analysis -- Chapter 21 Intersection Analysis and Rare Variant Association Studies -- Chapter 22 Variant Frequency Analysis -- Chapter 23 Variant Pathogenicity Prediction -- Part VI Prioritization -- Chapter 24 Variant Prioritization -- Chapter 25 Prioritization by Random Walk Analysis -- Chapter 26 Phenotype Analysis -- Chapter 27 Exomiser and Genomiser -- Chapter 28 Medical Interpretation -- Part VII Cancer -- Chapter 29 A (Very) Short Introduction to Cancer -- Chapter 30 Somatic Variants in Cancer -- Chapter 31 Tumor Evolution and Sample Purity -- Chapter 32 Driver Mutations and Mutational Signatures -- Appendix A Hints and Answers -- References -- Index

Computational Genome Analysis

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Author : Richard C. Deonier
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-12-27

Computational Genome Analysis written by Richard C. Deonier and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-27 with Science categories.

Computational Genome Analysis: An Introduction presents the foundations of key problems in computational molecular biology and bioinformatics. It focuses on computational and statistical principles applied to genomes, and introduces the mathematics and statistics that are crucial for understanding these applications. The book is appropriate for a one-semester course for advanced undergraduate or beginning graduate students, and it can also introduce computational biology to computer scientists, mathematicians, or biologists who are extending their interests into this exciting field. This book features: - Topics organized around biological problems, such as sequence alignment and assembly, DNA signals, analysis of gene expression, and human genetic variation - Presentation of fundamentals of probability, statistics, and algorithms - Implementation of computational methods with numerous examples based upon the R statistics package - Extensive descriptions and explanations to complement the analytical development - More than 100 illustrations and diagrams (some in color) to reinforce concepts and present key results from the primary literature - Exercises at the end of chapters From the reviews: "The book is useful for its breadth. An impressive variety of topics are surveyed...." Short Book Reviews of the ISI, June 2006 "It is a very good book indeed and I would strongly recommend it both to the student hoping to take this study further and to the general reader who wants to know what computational genome analysis is all about." Mark Bloom for the JRSS, Series A, Volume 169, p. 1006, October 2006 "Richard C. Deonier, Simon Tavare and Michael S. Waterman provide us wtih a 'roll up your sleeves and get dirty' (as the authors phrase it in their preface) introduction to the field of computational genome analysis...The book is carefully written and carefully edited..." Ralf Schmid for Genetic Research, Volume 87, p. 218, 2006

The Hitchhiker S Guide To Whole Exome Analysis

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Author : Shrey Gandhi
language : en
Publisher: Research in Genomics
Release Date : 2016-11-15

The Hitchhiker S Guide To Whole Exome Analysis written by Shrey Gandhi and has been published by Research in Genomics this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-15 with Science categories.

A handbook on computational analysis of whole exome sequence data

Rudolph S Pediatrics 24th Edition

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Author : Mark W. Kline
language : en
Publisher: McGraw Hill Professional
Release Date : 2026-01-30

Rudolph S Pediatrics 24th Edition written by Mark W. Kline and has been published by McGraw Hill Professional this book supported file pdf, txt, epub, kindle and other format this book has been release on 2026-01-30 with Medical categories.

The landmark pediatrics reference—updated with timely new content and more clinically relevant than ever Rudolph's Pediatrics has virtually defined the pediatric field for over a century, becoming one of the most important and well-respected pediatrics texts ever published. Renowned for its balance of clinical features and treatment of disease with underlying biological principles, this classic sourcebook has helped generations of pediatricians optimize their care of infants, children, and adolescents. This twenty-fourth edition of Rudolph's Pediatrics continues a long tradition of adapting its content to changes in our understanding of children's health and disease, providing an up-to-date, in-depth survey of pediatric medicine unmatched by any other text. With its algorithmic approach to pediatric systems, the book facilitates the diagnosis and treatment of both common and uncommon pediatric illnesses, and it reflects new technologies and advances in molecular medicine that continue to evolve with current thinking about normal childhood development and pediatric disease processes. Rudolph's Pediatrics, 24th Edition features: • New chapters on telemedicine and pandemics, and expanded section on behavioral health. • The most cohesive and consistent approach to clinical management of diseases and disorders of infants, children, and adolescents • Unmatched coverage of signs and symptoms • Expanded treatment algorithms • Expert coverage of general pediatrics and all the pediatric sub-specialties • Streamlined and consistent format for most chapters outlining Pathogenesis and Epidemiology, Clinical Manifestations, Diagnosis, Treatment, and Prevention • Hundreds of full-color illustrations and tables

Computational Genome Analysis An Introduction

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Author : Deonier
language : en
Publisher:
Release Date : 2007-10-01

Computational Genome Analysis An Introduction written by Deonier and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-01 with categories.

Harpers Illustrated Biochemistry 30th Edition

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Author : Victor W. Rodwell
language : en
Publisher: McGraw Hill Professional
Release Date : 2015-03-22

Harpers Illustrated Biochemistry 30th Edition written by Victor W. Rodwell and has been published by McGraw Hill Professional this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-22 with Medical categories.

Gain a thorough understanding of the principles ofbiochemistry as they relate to the study of clinical medicine A Doody's Core Title for 2017! THE BEST REVIEW FOR THE USMLE! The Thirtieth Edition of Harper’s Illustrated Biochemistry combines outstanding full-colorillustrations with authoritative integrated coverage of biochemical disease and clinical information. Using brevity and numerous medically relevant examples, Harper's presents a clear, succinct review of the fundamentals of biochemistry that every student must understand in order to succeed in medical school. All fifty-eight chapters emphasize the medical relevance of biochemistry Full-color presentation includes more than 600 illustrations Each chapter includes a section on BiomedicalImportance and a summary of the topics covered Review questions follow each of the eleven sections Case studies in every chapter emphasize the clinical relevance to biochemistry NEW coverage of toxic naturally-occurring amino acids; extraterrestrial biomolecules; computer-aided drug design; the role of complement cascade in bacterial and viral infection; secreted mediators of cell-cell signaling between leukocytes; the role of mast cells, basophils, andeosinophils; and the hazard of antioxidants that down-regulate radical signaling for apoptosis and increase risk of cancer Applauded by medical students for its current and engaging style, Harper's Illustrated Biochemistry is an essential for USMLE review and the single best reference for learning the clinical relevance of any biochemistry topic.

Science

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Author : John Michels (Journalist)
language : en
Publisher:
Release Date : 2010

Science written by John Michels (Journalist) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Science categories.

Williams Hematology 9e

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Author : Kenneth Kaushansky
language : en
Publisher: McGraw Hill Professional
Release Date : 2015-12-23

Williams Hematology 9e written by Kenneth Kaushansky and has been published by McGraw Hill Professional this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-23 with Medical categories.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The world's most highly regarded reference text on the mechanisms and clinical management of blood diseases A Doody's Core Title for 2020! Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. It is acknowledged worldwide as the leading hematology resource, with editors who are internationally regarded for their research and clinical achievements and authors who are luminaries in their fields. The Ninth Edition of Williams Hematology is extensively revised to reflect the latest advancements in basic science, translational pathophysiology, and clinical practice. In addition to completely new chapters, it features a full-color presentation that includes 700 photographs, 300 of which are new to this edition, and 475 illustrations. Recognizing that blood and marrow cell morphology is at the heart of diagnostic hematology, informative color images of the relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell morphology important to diagnosis. Comprehensive in its depth and breath, this go-to textbook begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.

Williams Hematology 10th Edition

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Author : Kenneth Kaushansky
language : en
Publisher: McGraw Hill Professional
Release Date : 2021-01-14

Williams Hematology 10th Edition written by Kenneth Kaushansky and has been published by McGraw Hill Professional this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-14 with Medical categories.

The landmark text that has guided generations of hematologists and related practitioners―updated with the latest research findings and improved format and presentation Long revered for its comprehensiveness and extraordinary depth of detail, Williams Hematology provides essential coverage of the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood and marrow cells and coagulation proteins. The text contains a wealth of basic science and translational pathophysiology for optimal, lifelong learning. Experts in research and clinical hematology, the editors are known worldwide for their contributions to the field. This new edition contains everything that has made Williams Hematology the go-to resource for decades and has been updated with new chapters and critical new research into the molecular mechanisms responsible for hematological disorders and the impact on diagnosis and treatment. And the new format enables you to access each chapter via content modules covering key topics, with summaries, infographics, and cases―all linked to review questions for self-assessment. The full-color presentation integrates images of blood and tissue findings where they are cited in the text. NEW TO THIS EDITION: Updated and revised content reflecting the latest research and developments Convenient format that streamlines the learning process and improves retention Additional chapters added on: Immune Checkpoint Inhibitors Immune Cell Therapy: Chimeric Antigen Receptor T Cell Therapy Immune Cell Therapy Dendritic Cell and Natural Killer Cell Therapy The processes of cell death and survival Application of Big Data and Deep Learning in Hematology Williams Hematology Cases with multiple-choice questions including detailed explanations—perfect preparation for the boards Continuously updated online content with comprehensive drug therapy database and other resources