Clinical Epigenetics
DOWNLOAD
Download Clinical Epigenetics PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Clinical Epigenetics book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Clinical Epigenetics
DOWNLOAD
Author : Luke B. Hesson
language : en
Publisher: Springer Nature
Release Date : 2019-08-31
Clinical Epigenetics written by Luke B. Hesson and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-31 with Medical categories.
In genetic pathology, epigenetic testing is rare and under utilised. In this book, we introduce epigenetics to a non-expert scientific audience and describe current and future clinical utility of epigenetic testing. By focussing on epigenetics in human disease this book will guide professionals (scientists and clinicians) to understand how epigenetics is relevant in a clinical context, and to implement epigenetic testing in diagnostic laboratories. The book begins with a historical perspective of genetics and epigenetics and describes the work of pioneers who have helped shape these fields. The various mechanisms by which epigenetics can regulate the function of the genome is described. These include DNA methylation, histone modifications, histone variants, nucleosome positioning, cis-regulatory elements, non-coding RNAs and the three-dimensional organisation of chromatin in the nucleus. These are discussed in the context of embryological development, cancer and imprinting disorders, and include examples of epigenetic changes that can be used in diagnosis, prediction of therapeutic response, prognostication or disease monitoring. Finally, for those wishing to implement epigenetic testing in a diagnostic setting, the book includes a case study that illustrates the clinical utility of epigenetic testing.
Medical Epigenetics
DOWNLOAD
Author :
language : en
Publisher: Academic Press
Release Date : 2021-08-27
Medical Epigenetics written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-27 with Medical categories.
**Selected for Doody's Core Titles® 2024 in Clinical Genetics**Medical Epigenetics, Second Edition provides a comprehensive analysis of epigenetics in health management, across a broad spectrum of disease categories and specialties, and with a focus on human systems, epigenetic diseases that affect these systems, and evolving modes of epigenetic-based treatment. Here, more than 40 leading researchers examine how each human system is affected by epigenetic maladies, offering an all-in-one resource on medical epigenetics not only for those directly involved with health care, but investigators in life sciences, biotech companies, graduate students, and others who are interested in applied aspects of epigenetics. Incorporating both diagnostic and prognostic epigenetic approaches, this volume also fully supports the application of epigenetics in precision medicine. This second edition of Medical Epigenetics, a volume in the Translational Epigenetics series, has been fully revised to address recent advances in disease epigenetics and role of epigenetics in precision medicine, with all-new chapters on skin cancer epigenetics, network analysis in medical epigenetics, machine learning in epigenetic diseases, and clinical trials of epigenetics drugs. - Features chapters from leading researchers and clinicians dedicated to the burgeoning role of epigenetics in medical practice - Covers emerging topics, including twin epigenetics, as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine - Organized from system disorders to multi-system disorders that involve epigenetic aberrations - Examines the role of epigenetics in precision medicine
Clinical Epigenetics Current Research
DOWNLOAD
Author : Elias Foster
language : en
Publisher: American Medical Publishers
Release Date : 2021-11-16
Clinical Epigenetics Current Research written by Elias Foster and has been published by American Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-16 with Medical categories.
Epigenetics delves into the heritable phenotype changes which do not involve changes in DNA sequence. Epigenetics usually show changes that affect the activity of gene and expression along with any heritable phenotypic change. Epigenetics in medicine consist of the use of drugs and epigenome influencing techniques in order to treat medical conditions. Epigenetic mechanisms have three categories- DNA methylation, histone modifications and regulatory RNA. It influences many diseases like cancer, diabetes, mental illness and heart diseases. In such situation epigenetic therapy helps in influencing these pathways. This book brings forth some of the most innovative concepts and elucidates the unexplored aspects of epigenetics. The various advancements in epigenetics in medicine are glanced at and their applications as well as ramifications are looked at in detail. This book, with its detailed analyses and data, will prove immensely beneficial to professionals and students involved in this area at various levels.
Medical Epigenetics
DOWNLOAD
Author : Trygve Tollefsbol
language : en
Publisher: Academic Press
Release Date : 2016-06-21
Medical Epigenetics written by Trygve Tollefsbol and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-21 with Science categories.
Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine
Epigenetics In Precision Medicine
DOWNLOAD
Author : Jose Luis Garcia-Gimenez
language : en
Publisher: Elsevier
Release Date : 2021-11-12
Epigenetics In Precision Medicine written by Jose Luis Garcia-Gimenez and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-12 with Medical categories.
In recent years, knowledge of epigenetic mechanisms underlying disease onset and progression has proven crucial for the development of novel early diagnosis and prognosis biomarkers for patient stratification and precision medicine. Epigenetics in Precision Medicine, a new volume in the Translational Epigenetics series, provides a thorough discussion and overview of current developments in clinical epigenetics with special emphasis on epigenetic biomarkers that can be used for clinical diagnosis, prognosis, patient stratification, and treatment monitoring. Disease types discussed include cancer, metabolic disorders, neurodegenerative diseases, bone disease, and immune-related disorders. The book examines the challenges of advancing epigenetics research and translating findings to the clinic and drug discovery in each of these areas, as well as current solutions; chapter authors discuss how to leverage epigenomic technologies, applications, and tools, such as next-generation sequencing, to discover new epigenetic biomarkers in disease and drug studies. Epigenetics in Precision Medicine focuses on complex epigenetic mechanisms in several pathologies, and explores how epigenetics can power the advance of precision medicine, not only by improving in vitro diagnostic and prognostic tools, but by providing new therapeutic approaches to treat human disease. - Provides a thorough grounding in epigenetics-driven precision medicine, with emphasis on developing and implementing early diagnosis and prognosis biomarkers, and supporting patient stratification - Empowers researchers and clinicians to incorporate epigenetics in new disease research, drug discovery, and clinical practice - Features chapter contributions from international leaders in the field
Epigenetics In Human Disease
DOWNLOAD
Author : Trygve O. Tollefsbol
language : en
Publisher: Academic Press
Release Date : 2012-07-26
Epigenetics In Human Disease written by Trygve O. Tollefsbol and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-26 with Medical categories.
Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs
Handbook Of Epigenetics
DOWNLOAD
Author : Trygve Tollefsbol
language : en
Publisher: Academic Press
Release Date : 2010-11-21
Handbook Of Epigenetics written by Trygve Tollefsbol and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-21 with Science categories.
Epigenetics is considered by many to be the "new genetics" because of the overwhelming evidence of the contribution of non-genetic factors such as nutrition, environment, and chemical exposure on gene expression. The effects of epigenetics are vast, including tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation and genomic imprinting and aging. Aberrations of epigenetics influence many diseases for which clinical intervention is already in place, and many novel epigenetic therapies for cancer, immune disorders, neurological and metabolic disorders, and imprinting diseases are on the horizon. This comprehensive collection of reviews written by leaders in the field of epigenetics provides a broad view of this important and evolving topic. From molecular mechanisms and epigenetic technology to discoveries in human disease and clinical epigenetics, the nature and applications of the science will be presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders. Contributions by leading international investigators involved in molecular research and clinical and therapeutic applications Integrates methods and biological topics with basic and clinical discoveries Includes coverage of new topics in epigenetics such as prions, regulation of long-term memory by epigenetics, metabolic aspects of epigenetics, and epigenetics of neuronal disorders
Handbook Of Epigenetics
DOWNLOAD
Author : Trygve O Tollefsbol
language : en
Publisher: Academic Press
Release Date : 2017-07-10
Handbook Of Epigenetics written by Trygve O Tollefsbol and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-10 with Science categories.
Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. - Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field - Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine - Written at a verbal and technical level that can be understood by scientists and college students - Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials
Epigenetic Biomarkers And Diagnostics
DOWNLOAD
Author : Jose Luis Garcia-Gimenez
language : en
Publisher: Academic Press
Release Date : 2015-12-07
Epigenetic Biomarkers And Diagnostics written by Jose Luis Garcia-Gimenez and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-07 with Science categories.
Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. - Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics - Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics - Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications - Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases - Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies
Clinical Epigenetics Mechanisms Diagnosis And Prognosis
DOWNLOAD
Author : Elias Foster
language : en
Publisher:
Release Date : 2019-06-18
Clinical Epigenetics Mechanisms Diagnosis And Prognosis written by Elias Foster and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-18 with categories.
The study of the changes in the heritable phenotypes, which do not involve any alterations in the DNA sequence, is known as epigenetics. It usually denotes the changes which affect gene activity and expression. It can also be used to describe heritable phenotypic changes. The effects on the physiological and cellular phenotypic traits often result from external or environmental factors. Epigenetics has several medical applications. It plays a major role in congenital genetic diseases such as Prader-Willi syndrome and Angelman syndrome. The study of epigenetic modifications to the DNA of cancer cells, which do not involve a change in the nucleotide sequence, is called cancer epigenetics. The ever-growing need of advanced technology is the reason that has fueled the research in the field of clinical epigenetics in recent times. The objective of this book is to give a general view of the different areas of clinical epigenetics and their applications. As this field is emerging at a rapid pace, the contents of this book will help the readers understand the modern concepts and applications of the subject.