Cell Cycle Regulation
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Cell Cycle Control
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Author : Michele Pagano
language : en
Publisher: Springer Science & Business Media
Release Date : 1998-06-08
Cell Cycle Control written by Michele Pagano and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-06-08 with Medical categories.
Addressing the regulation of the eukaryotic cell cycle, this book brings together experts to cover all aspects of the field, clearly and unambiguously, delineating what is commonly accepted in the field from the problems that remain unsolved. It will thus appeal to a large audience: basic and clinical scientists involved in the study of cell growth, differentiation, senescence, apoptosis, and cancer, as well as graduates and postgraduates.
Cell Cycle Control
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Author : Tim Humphrey
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Cell Cycle Control written by Tim Humphrey and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Science categories.
The fundamental question of how cells grow and divide has perplexed biologists since the development of the cell theory in the mid-19th century, when it was recognized by Virchow and others that “all cells come from cells.” In recent years, considerable effort has been applied to the identification of the basic molecules and mechanisms that regulate the cell cycle in a number of different organisms. Such studies have led to the elucidation of the central paradigms that underpin eukaryotic cell cycle control, for which Lee Hartwell, Tim Hunt, and Paul Nurse were jointly awarded the Nobel Prize for Medicine and Physiology in 2001 in recognition of their seminal contributions to this field. The importance of understanding the fundamental mechanisms that modulate cell division has been reiterated by relatively recent discoveries of links between cell cycle control and DNA repair, growth, cellular metabolism, development, and cell death. This new phase of integrated cell cycle research provides further challenges and opportunities to the biological and medical worlds in applying these basic concepts to understanding the etiology of cancer and other proliferative diseases.
Cell Cycle Regulation
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Author : Philipp Kaldis
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-06-02
Cell Cycle Regulation written by Philipp Kaldis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-02 with Science categories.
This book is a state-of-the-art summary of the latest achievements in cell cycle control research with an outlook on the effect of these findings on cancer research. The chapters are written by internationally leading experts in the field. They provide an updated view on how the cell cycle is regulated in vivo, and about the involvement of cell cycle regulators in cancer.
The Cell Cycle
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Author : Valerie W. Hu
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Cell Cycle written by Valerie W. Hu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Interest in the cell cycle has grown explosively in recent years as a result of the identification of key cell cycle regulators and their substrates. Aside from enhancing our understanding of normal cellular growth controls, this new knowledge has also becn valuable in elucidating mechanisms of growth deregulation which occur in diseased states, such as cancer and, in some instances, viral or parasitic infections. The Thirteenth Washington International Spring Symposium was organized with the intention of bringing together scientists working on different aspects of the cell cycle. Scientific topics presented ranged from molecular regulators and effectors to mitosis specific changes in cell architecture to the role of the cell cycle in development and disease. The goal of this gathering was to help formulate a more comprehensive and integrated picture of events driving and being driven by the cell cycle, as well as to evaluate the possibilities for clinical application of this knowledge. This symposium, held in Washington, D.C. from May 10-14, 1993, was attended by more than 400 scientists from 20 countries, including many of the scientific leaders in this field. This volume contains most of the papers presented at the seven plenary sessions in addition to selected contributions from a total of nine special oral and poster sessions.
Regulation Of The Eukaryotic Cell Cycle
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Author : Joan Marsh
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30
Regulation Of The Eukaryotic Cell Cycle written by Joan Marsh and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Science categories.
Comprised of the latest developments in cell cycle research, it analyzes the principles underlying the control of cell division. Offers a framework for future investigation, especially that aimed toward understanding and treatment of cancer.
The Cell Cycle
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Author : David Owen Morgan
language : en
Publisher: New Science Press
Release Date : 2007
The Cell Cycle written by David Owen Morgan and has been published by New Science Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Science categories.
The Cell Cycle: Principles of Control provides an engaging insight into the process of cell division, bringing to the student a much-needed synthesis of a subject entering a period of unprecedented growth as an understanding of the molecular mechanisms underlying cell division are revealed.
Cell Cycle Regulation
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Author : James R. Jr. Jeter
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Cell Cycle Regulation written by James R. Jr. Jeter and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Cell Cycle Regulation describes the interaction of the nuclear genome, the cytoplasmic pools, the organelles, the cell surface, and the extracellular environment that govern the cell cycle regulation. Comprised of 12 chapters, this book includes cell cycle regulation around nuclear chromatin modulation and some aspects of chromatin modification and its effects on gene expression. The opening chapters describe the macromolecular structure of chromatin subunits and the types and kinds of postsynthetic modifications occurring on histones, such as acetylation, methylation, and phosphorylation. The subsequent chapter deals extensively on histone phosphorylation, especially histone H1, H1M, H2A, and H3, during the cell cycle. Another chapter describes a selective histone leakage from nuclei during isolation accounting for the role of histone acetylation and phosphorylation in gene expression. This book goes on examining the assembly of microtubules and structural analysis on the regulatory role of calcium into a pattern for mitosis regulation. Other chapters discuss the methods used to measure intracellular pH changes as a function of the cell cycle of Physarum and the quantitative and qualitative changes taking place during the various phases of the cell cycle. The use of mammalian cell fusion to study cell cycle regulation and the protein synthesis regulation during the cell cycle in Chlamydomonas reinhardi are then discussed. The final chapters focus on the regulation of expression of an inducible structural gene during the cell cycle of the green alga Chlorella. The chapters provide evidence for a model of positive and negative oscillatory control of inducible gene expression. An analysis of the expression of cytoplasmic genes as a function of the cell cycle using pedigrees of a large number of individual yeast cells is also included. This book will appeal to a wide variety of life scientists and to molecular, cellular, and developmental biologists.
Progress In Cell Cycle Research
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Author : Laurent Meijer
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Progress In Cell Cycle Research written by Laurent Meijer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The "Progress in Cell Cycle Research" series is dedicated to serve as a collection of reviews on various aspects of the cell division cycle, with special emphasis on less studied aspects. We hope this series will continue to be helpful to students, graduates and researchers interested in the cell cycle area and related fields. We hope that reading of these chapters will constitute a "point of entry" into specific aspects of this vast and fast moving field of research. As PCCR4 is being printed several other books on the cell cycle have appeared (ref. 1-3) which should complement our series. This fourth volume of PCCR starts with a review on RAS pathways and how they impinge on the cell cycle (chapter 1). In chapter 2, an overview is presented on the links between cell anchorage -cytoskeleton and cell cycle progression. A model of the Gl control in mammalian cells is provided in chapter 3. The role of histone acetylation and cell cycle contriol is described in chapter 4. Then follow a few reviews dedicated to specific cell cycle regulators: the 14-3-3 protein (chapter 5), the cdc7/Dbf4 protein kinase (chapter 6), the two products of the pI6/CDKN2A locus and their link with Rb and p53 (chapter 7), the Ph085 cyclin-dependent kinases in yeast (chapter 9), the cdc25 phophatase (chapter 10), RCCI and ran (chapter 13). The intriguing phosphorylation dependent prolyl-isomerization process and its function in cell cycle regulation are reviewed in chapter 8.
Cell Cycle Regulators In Cancer
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Author : Kiran Musunuru
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 1997
Cell Cycle Regulators In Cancer written by Kiran Musunuru and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
Cancer can be tersely yet accurately described as improper cell proliferation. To understand cancer we must first understand the genetic and biochemical mechanisms responsible for proper cell proliferation. The last five years have witnessed the characterization of several families of novel proteins involved in cell cycle regulation and the clarification of the biochemical processes in which they participate. This book illuminates the roles of various cell cycle regulators - cyclins, cyclindependent kinases (CDKs) and CDK inhibitors - and describes the connections between these proteins and oncogenesis. Possible ways of clinical intervention that might be developed into potent cancer therapies are also explored. By chronologically documenting the discovery of cell regulators and providing clear, brief synopses of current findings, this work offers an easily accessible guide for both students and experienced researchers. An extensive list of excellent reviews for further reading rounds off the reference value of this timely publication.
Cell Cycle Control
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Author : Anna Castro
language : en
Publisher: Springer Nature
Release Date : 2024-02-23
Cell Cycle Control written by Anna Castro and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-23 with Science categories.
This detailed volume collects techniques to study the highly regulated cell cycle process. Beginning with chapters investigating these processes and assessing how cells respond when these complicated pathways are simplified by using synthetic biology and in vitro reconstitutions, the book continues by exploring how cells sense and respond to environmental conditions, different model systems and cellular types used to visualize cellular architecture during cell division, as well as innovative single cell microscopy techniques to highlight the heterogeneity of the cell population with respect to cell cycle progression. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cell Cycle Control: Methods and Protocols serves as an ideal guide for researchers attempting to elucidate this vital area of cell biology.