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C Elegans


C Elegans
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C Elegans


C Elegans
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Author : Kevin Strange
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-05

C Elegans written by Kevin Strange and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-05 with Medical categories.


Molecular biology has driven a powerful reductionist, or “molecule-c- tric,” approach to biological research in the last half of the 20th century. Red- tionism is the attempt to explain complex phenomena by defining the functional properties of the individual components of the system. Bloom (1) has referred to the post-genome sequencing era as the end of “naïve reductionism. ” Red- tionist methods will continue to be an essential element of all biological research efforts, but “naïve reductionism,” the belief that reductionism alone can lead to a complete understanding of living organisms, is not tenable. Organisms are clearly much more than the sum of their parts, and the behavior of complex physiological processes cannot be understood simply by knowing how the parts work in isolation. Systems biology has emerged in the wake of genome sequencing as the s- cessor to reductionism (2–5). The “systems” of systems biology are defined over a wide span of complexity ranging from two macromolecules that interact to carry out a specific task to whole organisms. Systems biology is integrative and seeks to understand and predict the behavior or “emergent” properties of complex, multicomponent biological processes. A systems-level characteri- tion of a biological process addresses the following three main questions: (1) What are the parts of the system (i. e.



Caenorhabditis Elegans


Caenorhabditis Elegans
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Author :
language : en
Publisher: Academic Press
Release Date : 2011-11-23

Caenorhabditis Elegans written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-23 with Technology & Engineering categories.


An updated edition of the classic Methods in Cell Biology volume 48, this book emphasizes diverse methods and technologies needed to investigate C. elegans, both as an integrated organism and as a model system for research inquiries in cell, developmental, and molecular biology, as well as in genetics and pharmacology. By directing its audience to tried-and-true and cutting-edge recipes for research, this comprehensive collection is intended to guide investigators of C. elegans for years to come. - Diverse, up-to-date techniques covered will be useful to the broadening community of C. elegans researchers for years to come - Chapters written by leaders in the field - Tried and true methods deliver busy researchers a one-stop compendium of essential protocols



C Elegans


C Elegans
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Author : Ian A. Hope
language : en
Publisher: OUP Oxford
Release Date : 1999-12-09

C Elegans written by Ian A. Hope and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-12-09 with Science categories.


Caenorhabditis Elegans has been a popular model organism for biological research for over thirty years and has been used to investigate many aspects of animal development, for example apoptosis, the Hox genes, signal transduction pathways, and the development of the nervous system. It has recently taken on new importance with the publication of the entire genome sequence in 1998. The first chapter gives all the basic information on C. elegans required to use it: it's natural history, anatomy, life cycle, development, and evolution. Information on how to obtain, grow, and maintain C. elegans for use as a model system is given in Chapter 4. Chapters 2 and 3 describe the genome project and show how to use genome sequence information by searching the database for homologues using different search methods and then how to analyse the search data. The next chapter gives the essential practical details of transformation and common uses for the technique. Chapter 6 covers reverse genetics and describes strategies for gene inactivation that are known to work in C elegans: epigenetic inactivation and mutational germ line inactivation. Chapter 7 is designed to help the user analyse phenotype by microscopy and includes Normaski, fluorescence, 4-dimensional, and electron microscopy. Techniques for studying the neurobiology of C. elegans are given in chapter 8. Chapter 9 describes the three commonly used approaches for studying gene expression and Chapter 10 deals with the common methods of molecular biology essential for gene characterization. C. elegans is not the ideal organism for biochemical studies, but chapter 11 describes several procedures for producing biochemically useful quantities of pure tissues. The final chapter is about conventional genetics and details the standard procedures for selfing and crossing; mutagenesis and mutant screening; characterization of mutants; gene mapping; temperature-shift experiments and mosaic analysis. Caenorhabditis Elegans: A Practical Approach will therefore provide all the background information necessary for use of C. elegans as a model system.



Caenorhibditus Elegans Modern Biological Analysis Of An Organism


Caenorhibditus Elegans Modern Biological Analysis Of An Organism
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Author :
language : en
Publisher: Academic Press
Release Date : 1995-10-16

Caenorhibditus Elegans Modern Biological Analysis Of An Organism written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-10-16 with Science categories.


The first of its kind, this laboratory handbook emphasizes diverse methods and technologies needed to investigate C. elegans, both as an integrated organism and as a model system for research inquiries in cell,developmental, and molecular biology, as well as in genetics and pharmacology. Four primary sections--Genetic and Culture Methods, Neurobiology, Cell and Molecular Biology, and Genomics and Informatics--reflect the cross-disciplinary nature of C. elegans research. Because C. elegans is a simple and malleable organism with a small genome and few cell types, it provides an elegant demonstration of functions fundamental to multicellular organisms. The discipline has greatly expanded as researchers continue to find this small soil nematode to be the model of choice for studying specific pathways, stages of development, and cell types. By directing its audience not just to tried-and-true recipes for research, but also to databases and other innovative sources of information, this comprehensive collection is intended to guide investigators of C. elegans for years to come.First single-source book detailing explanations of current and classic C. elegans methodologiesDiversity and scope of techniques covered expected to be useful to the broadening community of C. elegans researchers for years to comeTechniques range from reverse genetics and mutagenesis, to laser ablation and electrophysiology, to in situ hybridization and DNA sequencing methodsAppendices include resource information important to the C. elegans community, including the C. elegans Genetics Center and Internet resources like the Worm Community System and ACeDBIllustrated with more than 100 tables and figures



Model Organisms In Aging Research Caenorhabditis Elegans


Model Organisms In Aging Research Caenorhabditis Elegans
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Author : Maria Olivia Casanueva
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-11

Model Organisms In Aging Research Caenorhabditis Elegans written by Maria Olivia Casanueva and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-11 with Science categories.




The Nematode Caenorhabditis Elegans


The Nematode Caenorhabditis Elegans
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Author : William Barry Wood
language : en
Publisher:
Release Date : 1988

The Nematode Caenorhabditis Elegans written by William Barry Wood and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Science categories.




The Neurobiology Of C Elegans


The Neurobiology Of C Elegans
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Author :
language : en
Publisher: Elsevier
Release Date : 2006-02-02

The Neurobiology Of C Elegans written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-02-02 with Medical categories.


The Neurobiology of C. elegans assembles together a series of chapters describing the progress researchers have made toward solving some of the major problems in neurobiology with the use of this powerful model organism. The first chapter is an introduction to the anatomy of the C. elegans nervous system. This chapter provides a useful introduction to this system and will help the reader who is less familiar with this system understand the chapters that follow. The next two chapters on learning, conditioning and memory and neuronal specification and differentiation, summarize the current state of the C. elegans field in these two major areas of neurobiology. The remaining chapters describe studies in C. elegans that have provided particularly exciting insights into neurobiology.



Movement Disorders


Movement Disorders
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Author : Mark S. LeDoux
language : en
Publisher: Elsevier
Release Date : 2005-01-25

Movement Disorders written by Mark S. LeDoux and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-01-25 with Science categories.


The use of animal models is a key aspect of scientific research in numerous fields of medicine. This book vigorously examines the important contributions and application of animal models to the understanding of human movement disorders and will serve as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. A vital feature of this book is an accompanying DVD with video clips of human movement disorders and their corresponding animal models. The book is divided into sections on Parkinson disease, Huntington disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders.* Provides a single comprehensive resource on animal models of movement disorders that academic clinicians, translational researchers, and basic neuroscientists can refer to* Includes contributions by expert movement disorder clinicians and top-level researchers in the field* Features a DVD containing over 170 video clips of human movement disorders and the corresponding animal models



Molecular Biochemistry And Physiology Of Helminth Neuromuscular Systems


Molecular Biochemistry And Physiology Of Helminth Neuromuscular Systems
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Author : David Halton
language : en
Publisher: Cambridge University Press
Release Date : 1996

Molecular Biochemistry And Physiology Of Helminth Neuromuscular Systems written by David Halton and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.


This collection of articles, edited by D. W. Halton, is the specially commissioned supplement to the journal Parasitology, volume 113.



Caenorhabditis Elegans Cell Biology And Physiology


Caenorhabditis Elegans Cell Biology And Physiology
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Author : Joel Rothman
language : en
Publisher: Academic Press
Release Date : 2012-01-16

Caenorhabditis Elegans Cell Biology And Physiology written by Joel Rothman and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-16 with Medical categories.


The second part of an updated edition of the classic Methods in Cell Biology, Volume 48, this book emphasizes diverse methods and technologies needed to investigate C. elegans, both as an integrated organism and as a model system for research inquiries in cell, developmental, and molecular biology, as well as in genetics and pharmacology. By directing its audience to tried-and-true and cutting-edge recipes for research, this comprehensive collection is intended to guide investigators of C. elegans for years to come. Diverse, up-to-date techniques covered will be useful to the broadening community of C. elegans researchers for years to come Chapters written by leaders in the field Tried and true methods deliver busy researchers a one-stop compendium of essential protocols