Bioprocess Intensification
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Bioprocess Intensification
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Author : Dirk Holtmann
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2024-07-01
Bioprocess Intensification written by Dirk Holtmann and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-01 with Science categories.
Application of Process Intensification (PI) presents a set of radically innovative principles in process and equipment design, which can bring significant benefits in terms of process efficiency, capital and operating expenses, quality, process safety, and sustainability. Typical approaches in bioprocess intensification are the reduction of the number of production steps, continuous processing, integrated processes, and alternative energy inputs.
Bioprocess Intensification
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Author : Dirk Holtmann
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2024-07-01
Bioprocess Intensification written by Dirk Holtmann and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-01 with Science categories.
Application of Process Intensification (PI) presents a set of radically innovative principles in process and equipment design, which can bring significant benefits in terms of process efficiency, capital and operating expenses, quality, process safety, and sustainability. Typical approaches in bioprocess intensification are the reduction of the number of production steps, continuous processing, integrated processes, and alternative energy inputs.
Process Control Intensification And Digitalisation In Continuous Biomanufacturing
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Author : Ganapathy Subramanian
language : en
Publisher: John Wiley & Sons
Release Date : 2021-12-15
Process Control Intensification And Digitalisation In Continuous Biomanufacturing written by Ganapathy Subramanian and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-15 with Technology & Engineering categories.
Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing Explore new trends in continuous biomanufacturing with contributions from leading practitioners in the field With the increasingly widespread acceptance and investment in the ??technology, the last decade has demonstrated the utility of continuous ??processing in the pharmaceutical industry. In Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing, distinguished biotechnologist Dr. Ganapathy Subramanian delivers a comprehensive exploration of the potential of the continuous processing of biological products and discussions of future directions in advancing continuous processing to meet new challenges and demands in the manufacture of therapeutic products. A stand-alone follow-up to the editor’s Continuous Biomanufacturing: Innovative Technologies and Methods published in 2017, this new edited volume focuses on critical aspects of process intensification, process control, and the digital transformation of biopharmaceutical processes. In addition to topics like the use of multivariant data analysis, regulatory concerns, and automation processes, the book also includes: Thorough introductions to capacitance sensors to control feeding strategies and the continuous production of viral vaccines Comprehensive explorations of strategies for the continuous upstream processing of induced microbial systems Practical discussions of preparative hydrophobic interaction chromatography and the design of modern protein-A-resins for continuous biomanufacturing In-depth examinations of bioprocess intensification approaches and the benefits of single use for process intensification Perfect for biotechnologists, bioengineers, pharmaceutical engineers, and process engineers, Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing is also an indispensable resource for chemical engineers seeking a one-stop reference on continuous biomanufacturing.
Process Control Intensification And Digitalisation In Continuous Biomanufacturing
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Author : Ganapathy Subramanian
language : en
Publisher: John Wiley & Sons
Release Date : 2021-12-20
Process Control Intensification And Digitalisation In Continuous Biomanufacturing written by Ganapathy Subramanian and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-20 with Technology & Engineering categories.
Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing Explore new trends in continuous biomanufacturing with contributions from leading practitioners in the field With the increasingly widespread acceptance and investment in the ??technology, the last decade has demonstrated the utility of continuous ??processing in the pharmaceutical industry. In Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing, distinguished biotechnologist Dr. Ganapathy Subramanian delivers a comprehensive exploration of the potential of the continuous processing of biological products and discussions of future directions in advancing continuous processing to meet new challenges and demands in the manufacture of therapeutic products. A stand-alone follow-up to the editor’s Continuous Biomanufacturing: Innovative Technologies and Methods published in 2017, this new edited volume focuses on critical aspects of process intensification, process control, and the digital transformation of biopharmaceutical processes. In addition to topics like the use of multivariant data analysis, regulatory concerns, and automation processes, the book also includes: Thorough introductions to capacitance sensors to control feeding strategies and the continuous production of viral vaccines Comprehensive explorations of strategies for the continuous upstream processing of induced microbial systems Practical discussions of preparative hydrophobic interaction chromatography and the design of modern protein-A-resins for continuous biomanufacturing In-depth examinations of bioprocess intensification approaches and the benefits of single use for process intensification Perfect for biotechnologists, bioengineers, pharmaceutical engineers, and process engineers, Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing is also an indispensable resource for chemical engineers seeking a one-stop reference on continuous biomanufacturing.
Cell Culture Engineering And Technology
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Author : Ralf Pörtner
language : en
Publisher: Springer Nature
Release Date : 2022-02-20
Cell Culture Engineering And Technology written by Ralf Pörtner and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-20 with Medical categories.
This contributed volume is dedicated towards the progress achieved within the last years in all areas of Cell Culture Engineering and Technology. It comprises contributions of active researchers in the field of cell culture development for the production of recombinant proteins, cell line development, cell therapy and gene therapy, with consideration of media development, process scale-up, reactor design, monitoring and control and model-assisted strategies for process design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. This book is conceived for graduate students, postdoctoral fellows and researchers interested in the latest developments in Cell Engineering.
Bioprospecting Of Microorganism Based Industrial Molecules
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Author : Sudhir Pratap Singh
language : en
Publisher: John Wiley & Sons
Release Date : 2021-11-30
Bioprospecting Of Microorganism Based Industrial Molecules written by Sudhir Pratap Singh and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-30 with Science categories.
Discover a comprehensive and current overview of microbial bioprospecting written by leading voices in the field In Bioprospecting of Microorganism-Based Industrial Molecules, distinguished researchers and authors Sudhir P. Singh and Santosh Kumar Upadhyay deliver global perspectives of bioprospecting of biodiversity. The book covers diverse aspects of bioprospecting of microorganisms demonstrating biomass value of nutraceutical, pharmaceutical, biomedical, and bioenergetic importance. The authors present an amalgamation of translational research on bioresource utilization and ecological sustainability that will further the reader’s knowledge of the applications of different microbial diversity and reveal new avenues of research investigation. Readers will also benefit from: A thorough introduction to microbial biodiversity and bioprospecting An exploration of anti-ageing and skin lightening microbial products and microbial production of anti-cancerous biomolecules A treatment of UV protective compounds from algal biodiversity and polysaccharides from marine microalgal sources Discussions of microbial sources of insect toxic proteins and the role of microbes in bio-surfactants production Perfect for academics, scientists, researchers, graduate and post-graduate students working and studying in the areas of microbiology, food biotechnology, industrial microbiology, plant biotechnology, and microbial biotechnology, Bioprospecting of Microorganism-Based Industrial Molecules is an indispensable guide for anyone looking for a comprehensive overview of the subject.
Intensification Of Biobased Processes
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Author : Andrzej Gorak
language : en
Publisher: Royal Society of Chemistry
Release Date : 2018-06-18
Intensification Of Biobased Processes written by Andrzej Gorak and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-18 with Science categories.
The first book dedicated entirely to this area, Intensification of Biobased Processes provides a comprehensive overview of modern process intensification technologies used in bioprocessing.
Bioprocess Intensification Of Antibiotic Production Using Functionalized Polyhipe Polymers
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Author : Teresa Manguangua Ndlovu
language : en
Publisher:
Release Date : 2009
Bioprocess Intensification Of Antibiotic Production Using Functionalized Polyhipe Polymers written by Teresa Manguangua Ndlovu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
This study used "Streptomyces coelicolor" A3(2) as a model organism to study the potential for process intensification in antibiotic production using solid phase growth. This organism produces three chromosomally encoded antibiotics, actinorhodin, prodigiosin, and calcium dependent antibiotic (CDA), and one plasmid encoded antibiotic methylamycin. In this study the production of prodigiosin was the focus for this process intensification. A novel technique was developed in the preparation of the bacterial support (PHP) , which ensures a well-controlled internal architecture. Solid phase growth on this matrix was shown to support the production of prodigiosin and actinorhodin. The growth of "Streptomyces coelicolor" A3(2) on this nano-structured, macro-porous, polymeric support with hierarchic connectivity, generically known as PolyHIPE polymer. Variations of PHP were investigated and compared with conventional flask growth; the production of prodigiosin in PHP was demonstrated to exceed that in flask growth, offering the potential for an order of magnitude improvement in volumetric productivity. A micro-bioreactor was designed to improve spore penetration, the distribution of cells, viability and nutrient supply. Growth was observed by electron microscopy, SEM and TEM. It was operated as a forced inoculation of pre-germinated spore suspension in modified R5 media, this micro-bioreactor enhanced productivity by an order of magnitude. This study shows that bacterial growth rate and secondary metabolism are influenced by the pore size and surface chemistry of the support material. To understand these surfaces and scale dependent phenomena a series of microporous structures with different functionalised surfaces were generated. An initial proteomic study was performed to determine whether solid phase culture had lead to a fundamentally different pattern of growth. One dimensional SDS gel electrophoresis revealed some variations in the pattern of protein bands between samples from growth in flasks and on the different PHP supports. Mass spectrometric analysis by peptide mass fingerprinting, of differentially observed bands, revealed the predominance of elongation factor EF-tu in liquid culture and increases in S-adenosylmethionine synthetase and hypothetical protein SC07276 in solid phase culture.
Oxidoreductive Bioprocess Intensification Through Reaction Engineering And Enzyme Immobilization
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Author : Jordi Solé Ferré
language : en
Publisher:
Release Date : 2020
Oxidoreductive Bioprocess Intensification Through Reaction Engineering And Enzyme Immobilization written by Jordi Solé Ferré and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Microreactor Technology And Process Intensification
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Author : Yong Wang
language : en
Publisher:
Release Date : 2005
Microreactor Technology And Process Intensification written by Yong Wang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Language Arts & Disciplines categories.
Microreaction technology, with its unprecedented heat and mass transfer advantages as well as uniform residence time and flow pattern, is one of the few technologies with potential to develop efficient, environmentally benign, and compact processes. Novel fabrication and processing techniques, equipment, and operational methods are resulting in spectacular developments that go beyond "traditional" chemical engineering. These new developments promise improvements in process plants, and lead to the transformation of our concept of chemical plants into compact, safe, energy-efficient, and environmentally sustainable processes. Microsystems are now available in many devices for commercial applications including: micromixers and microreactors as alternative to batch production in pharmaceutical and fine chemical industry, lab-on-chip devices, microsensors, advanced rapid throughput chemical and catalyst screening tools (e.g. combi), distributed or portable power and chemical production, distributed heating and cooling, and even out of this world applications with NASA. A wide diversity of subjects are discussed in this book ranging from catalysis to fuel processing to combinatorial techniques to separations to novel reactors all of which are enabled by microtechnology principles. World renowned pioneers (Klavs Jensen, Volker Hessel, Jennifer Holmgren, and Galip Akay) provide accounts on both historical developments and the current state of the art as well as insights into future research and development in microreactor and process intensification. Research and developments are presented by industry, universities, U.S. National Laboratories, and other laboratories located in the United States and throughout the world. It is composed of peer-reviewed chapters from both contributing and invited authors. The review and original research topics include (1) introductory and general overviews, (2) microreactors- including catalysts for microreactors, fuel processors, milli-second contact time catalysis, gas to liquid technology, and biomass conversion; and (3) process intensification such as micro mixers, reactive membranes, and intensification of separation operations.