Angiogenesis

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Angiogenesis

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Author : Thomas Adair
language : en
Publisher: Biota Publishing
Release Date : 2010-07-01

Angiogenesis written by Thomas Adair and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-01 with Medical categories.

Angiogenesis is the growth of blood vessels from the existing vasculature. The field of angiogenesis has grown enormously in the past 30 years, with only 40 papers published in 1980 and nearly 6000 in 2010. Why has there been this explosive growth in angiogenesis research? Angiogenic therapies provide a potential to conquer cancer, heart diseases, and more than 70 of life’s most threatening medical conditions. The lives of at least 1 billion people worldwide could be improved with angiogenic therapy, according to the Angiogenesis Foundation. In this little book, we provide a simple approach to understand the essential elements of the angiogenic process, we critique the most powerful angiogenesis assays that are used to discover proangiogenic and antiangiogenic substances, and we provide an in-depth physiological perspective on how angiogenesis is regulated in normal, healthy tissues of the human body. All tissues of the body require a continuous supply of oxygen to burn metabolic substrates that are needed for energy. Oxygen is conducted to these tissues by blood capillaries: more capillaries can improve tissue oxygenation and thus enhance energy production; fewer capillaries can lead to hypoxia and even anoxia in the tissues. This means that angiogenic therapies designed to control the growth and regression of blood capillaries can be used to improve the survival of poorly perfused tissues that are essential to the body (heart, brain, skeletal muscle, etc.) and to rid the body of unwanted tissues (tumors). Table of Contents: Overview of Angiogenesis / Angiogenesis Assays / Regulation: Metabolic Factors / Regulation: Mechanical Factors / Glossary / References / Author Biographies

Angiogenesis

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Author : William D. Figg
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-05-24

Angiogenesis written by William D. Figg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-24 with Medical categories.

Dr. Judah Folkman, “father of angiogenesis”, (1933-2008) was the Director of the Vascular Biology Program, Andrus Professor of Pediatric Surgery, and Professor of Cell Biology at Harvard University's Boston Children's Hospital. In the 1971 issue of The New England Journal of Medicine, he proposed the theory that tumor growth is angiogenesis dependent. This premise was the basis of this field of research and has become the focus of scientists worldwide. Because of Folkman's discovery and research, the possibilities of antiangiogenic and angiogenic therapy have broadened beyond cancer to many noncancerous diseases. This book represents the first collection in a volume of which Dr. Folkman is co-editor. Dr. Folkman authored nearly 400 original papers and more than 100 book chapters. Dr. William Figg is the chief of the Molecular and Clinical Pharmacology Program at the National Cancer Institute, National Institutes of Health. Over the past 15 years, his laboratory and clinic at the NCI have focused on the development of angiogenesis inhibitors. Dr. Figg has published more than 380 publications.

Tumor Angiogenesis

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Author : Dieter Marmé
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-05

Tumor Angiogenesis written by Dieter Marmé and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-05 with Medical categories.

Tumor angiogenesis is one of the most prominent mechanisms driving tumor development and progression. This book is written by internationally renowned experts. Part 1 describes the basic mechanisms. Tumor-angiogenic signaling pathways are presented as new potential targets for anti-angiogenic therapy. Part 2 reviews the efforts made to validate new targets and to show efficacy in animals. Part 3 is devoted to the clinical development of the novel anti-angiogenic drugs and their use in clinical practice.

Anti Angiogenic Functional And Medicinal Foods

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Author : Jack N. Losso
language : en
Publisher: CRC Press
Release Date : 2007-04-05

Anti Angiogenic Functional And Medicinal Foods written by Jack N. Losso and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-05 with Medical categories.

The ability to regulate and manipulate the generation or remodeling of blood vessels is key to the successful treatment of many chronic diseases, both oncological and non-oncological. Several bioactive compounds present in human diets are now known to exert an inhibitive effect on the either the signaling or construction of new blood vessels. The i

Angiogenesis And Vascularisation

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Author : Józef Dulak
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-02-10

Angiogenesis And Vascularisation written by Józef Dulak and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-10 with Medical categories.

The book presents the overview of the current knowledge in some fields of vascular biology, addressing cellular and molecular aspects of blood-vessel formation and their role in health and disease. The major factors involved in the formation of blood vessels are presented by scientists actively involved in this area of research. Special emphasis is put on the presentation of various molecular mechanisms not addressed in similar works to date. The book is divided into three parts. The first part describes the cells and mediators in angiogenesis. The significance of various populations of potential endothelial progenitors is particularly highlighted. The chapters of the second part focus on molecular mechanisms, with special emphasis on the role of hypoxia, gasotransmitters and reactive oxygen species as well as microRNAs in regulation of angiogenic processes. In the third part, the pathological aspects of disturbed – aggravated or impaired – vascularization are discussed and new modalities for potential therapies are presented. The book is intended for scientists and PhD students in the fields of vascular biology and cancer research. It may be of interest for medical professionals in the fields of cardiovascular disease, diabetes, oncology and rheumatoid arthritis.

Angiogenesis In Health Disease And Malignancy

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Author : Ali Salajegheh
language : en
Publisher: Springer
Release Date : 2016-03-10

Angiogenesis In Health Disease And Malignancy written by Ali Salajegheh and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-10 with Medical categories.

This book is about “Angiogenesis”. A process in which new vasculature is formed from pre-existing capillaries. Angiogenesis process is associated with the proliferation and growth of both physiologically normal and neoplastic tissues, through the formation of vascular supply, essential for delivering growth requirements such as oxygen and nutrients. The book describes more than 100 genes and their key regulatory functions in the context of normal healthy condition, disease and malignancy, cancer proliferation and progression. New insights into the role of angiogenesis and the therapeutic inhibition of its regulators are investigated, due to the great potential for exploitation in the development of a novel treatment for cancer. New scientists, junior researchers and biomedical science students will find this book an invaluable introductory reference to their insight about angiogenesis and angiogenic role of more than 100 angiogenes and their role in healthy, disease and malignant conditions.

Molecular Mechanisms Of Angiogenesis

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Author : Jean-Jacques Feige
language : en
Publisher: Springer
Release Date : 2014-05-27

Molecular Mechanisms Of Angiogenesis written by Jean-Jacques Feige and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-27 with Medical categories.

Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological conditions including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells...) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable blood proof neovessels. This book reviews recent advances in our understanding of the molecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observations into the context of developmental, post-natal and pathological neovascularization. The book was published under the auspices of the French Angiogenesis Society. Most contributors are prominent members of this Society or international researchers who have actively contributed to the Annual Meetings of the Society.

Angiogenesis

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Author : Steiner
language : en
Publisher: Birkhäuser
Release Date : 2013-03-09

Angiogenesis written by Steiner and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Social Science categories.

Principles Of Molecular Oncology

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Author : Miguel H. Bronchud
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-03-16

Principles Of Molecular Oncology written by Miguel H. Bronchud and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-16 with Medical categories.

Drawing on years of significant advances and developments, the editors of this third edition have thoroughly updated the highly praised first and second editions and added new chapters to reflect the knowledge emerging from research on genomics, proteomics, chemoprevention strategies, pharmacogenomics, new molecular targets, therapeutic monoclonal antibodies, and innovative cytotoxic and cytostatic small molecular-weight molecules.

Mechanisms Of Angiogenesis

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Author : Matthias Clauss
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-11-22

Mechanisms Of Angiogenesis written by Matthias Clauss and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-11-22 with Medical categories.

Is it advisable to go back from bedside to the bench? During the last decade, few topics encountered such a broad interest in bio- gy and medicine as angiogenesis. The amazing ability of the body to restore blood flow by induction of blood vessel growth as part of an adaptive process has alarmed physicians dealing with diseases in which angiogenesis is either exaggerated (as in tumors) or too slow (as in ischemic diseases of heart and brain). Not surprisingly, pro- and antiangiogenic strategies have found their way into clinical trials. For instance, for the USA, the NIH website in early 2004 displayed 38 clinical studies involving either pro- or antiangiogenic th- apies. Given the expected overwhelming wealth of clinical data, the question may be asked whether further exploration of biological mechanisms is required or whether results from the bedside are instructive enough to proceed. This question depends also on the progress of pro- and antiangiogenic clinical trials. In the following, I give a short overview about some of the progress that has been made in this field. Since Judah Folkman proposed antiangiogenic tumor therapy thirty years ago, it has become increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, antiangiogenic therapy has gained much attention as a potential adjunct to conventional c- cer therapy.