Snc 2014
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Istfa 2014
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Author : A. S. M. International
language : en
Publisher: ASM International
Release Date : 2014-11-01
Istfa 2014 written by A. S. M. International and has been published by ASM International this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-01 with Technology & Engineering categories.
This volume features the latest research and practical data from the premier event for the microelectronics failure analysis community. The papers address the symposium's theme, Exploring the Many Facets of Failure Analysis.
Dopamine Neuron Diversity In Circuits And Diseases
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Author : Jean-Francois Poulin
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-24
Dopamine Neuron Diversity In Circuits And Diseases written by Jean-Francois Poulin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-24 with Science categories.
Parkinson S Disease Cell Vulnerability And Disease Progression
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Author : Javier Blesa
language : en
Publisher: Frontiers Media SA
Release Date : 2016-01-04
Parkinson S Disease Cell Vulnerability And Disease Progression written by Javier Blesa and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-04 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
Download PDF Download EPUB Parkinson's disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars compacta and a consequent striatal dopamine deficiency. The pathogenesis of Parkinson's Disease remains unclear. Despite tremendous growth in recent years in our knowledge of the molecular basis of Parkinson's Disease and the molecular pathways of cell death important questions remain regarding why are substantia nigra cells especially vulnerable, which mechanisms underlie progressive cell loss or what do Lewy bodies or alpha-synuclein reveal about disease progression. Understanding the different vulnerability of the dopaminergic neurons from midbrain regions and the mechanisms whereby pathology becomes widespread are primary objectives of basic and clinical research in Parkinson's Disease. This e-Book discusses the etiopathogenesis of Parkinson's Disease, presenting a series of papers that provide up-to-date, state-of-the-art information on molecular and cellular mechanisms involved in the neurodegeneration process in the disease, the role of activation of functional anatomical organization of the basal ganglia and in particular habitual vs goal directed systems as a factor of neuronal vulnerability, the possibility that Parkinson's Disease coulb be a prion disease and how genetic factors linked to familial and sporadic forms of PD. We hope that this e-Book will stimulate the continuing efforts to understand the cell and physiological mechanisms underlying the origin of Parkinson's Disease.
Therapeutic Applications Of Dopamine D3 Receptor Function
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Author : Isabelle Boileau
language : en
Publisher: Springer Nature
Release Date : 2023-01-02
Therapeutic Applications Of Dopamine D3 Receptor Function written by Isabelle Boileau and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-02 with Medical categories.
The CTBN volume Therapeutic Applications of Dopamine D3 Receptor Function reviews the state of the knowledge on the dopamine D3 receptor and its role in human behavior and disease (i.e.: neuropsychiatric illnesses including schizophrenia, mood disorders, Parkinson’s disease, restless legs syndrome, addictions and substance use disorders). The volume is written by leading experts across multidisciplinary areas (imaging, biobehavioral testing and clinical trials, preclinical models / molecular pharmacology) converging on the therapeutic implications / potential of the D3 receptor. The D3 dopamine receptor is a member of the D2-like family of G protein-coupled receptors. It was cloned and characterized almost 25 years ago. A key feature of the D3 dopamine receptor system, which has attracted considerable attention, is its anatomical localization remarkably restricted to the limbic circuitry. This has spurred the hypothesis that D3 involvement could contribute to the pathophysiology of neuropsychiatric disorders (or to some features of neuropsychiatric disorders), including but not limited to psychosis, addictions and substance abuse, mood and movement disorders.
The Handbook Of Dopamine
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Author : Stephanie J. Cragg
language : en
Publisher: Academic Press
Release Date : 2025-07-04
The Handbook Of Dopamine written by Stephanie J. Cragg and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-04 with Medical categories.
The Handbook of Dopamine captures current understanding of dopamine biology in the brain, including anatomical organization of dopamine neurons, their molecular and genetic diversity, synaptic and circuit connectivity, receptor function and signalling, through to diverse roles in behaviors and finally, dysfunction in disease. This volume compiles a comprehensive set of perspectives from a large number of leading scientists working in dopamine research. The volume describes the current state-of-the-field, summarizing knowledge that has been transformed in the last decade through the advent and application of sophisticated new technologies. - Offers up-to-date review of dopamine biology across fields - Explores the function and regulation of dopamine neurons in healthy behavior and also dysfunction in disease - Includes historical and future perspectives in the field of dopamine research
Reelin Related Neurological Disorders And Animal Models
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Author : Laura Lossi
language : en
Publisher: Frontiers Media SA
Release Date : 2017-03-14
Reelin Related Neurological Disorders And Animal Models written by Laura Lossi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-14 with categories.
The Reeler mutation was so named because of the alterations in gait that characterize homozygous mice. Several decades after the description of the Reeler phenotype, the mutated protein was discovered and named Reelin (Reln). Reln controls a number of fundamental steps in embryonic and postnatal brain development. A prominent embryonic function is the control of radial neuronal migration. As a consequence, homozygous Reeler mutants show disrupted cell layering in cortical brain structures. Reln also promotes postnatal neuronal maturation. Heterozygous mutants exhibit defects in dendrite extension and synapse formation, correlating with behavioral and cognitive deficits that are detectable at adult ages. The Reln-encoding gene is highly conserved between mice and humans. In humans, homozygous RELN mutations cause lissencephaly with cerebellar hypoplasia, a severe neuronal migration disorder that is reminiscent of the Reeler phenotype. In addition, RELN deficiency or dysfunction is also correlated with psychiatric and cognitive disorders, such as schizophrenia, bipolar disorder and autism, as well as some forms of epilepsy and Alzheimer's disease. Despite the wealth of anatomical studies of the Reeler mouse brain, and the molecular dissection of Reln signaling mechanisms, the consequences of Reln deficiency on the development and function of the human brain are not yet completely understood. This Research Topic include reviews that summarize our current knowledge of the molecular aspects of Reln function, original articles that advance our understanding of its expression and function in different brain regions, and reviews that critically assess the potential role of Reln in human psychiatric and cognitive disorders.
Information Provided By The Global Environment Facility On Its Activities Relating To The Preparation Of National Communications And Biennial Update Reports
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Author : United Nations Framework Convention on Climate Change (Organization)
language : en
Publisher:
Release Date : 2015
Information Provided By The Global Environment Facility On Its Activities Relating To The Preparation Of National Communications And Biennial Update Reports written by United Nations Framework Convention on Climate Change (Organization) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Climatic changes categories.
Trade Policy Review
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Author :
language : en
Publisher:
Release Date : 2019
Trade Policy Review written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Foreign trade regulation categories.
The Lsta S Complete Credit Agreement Guide Second Edition
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Author : Michael Bellucci
language : en
Publisher: McGraw Hill Professional
Release Date : 2016-11-11
The Lsta S Complete Credit Agreement Guide Second Edition written by Michael Bellucci and has been published by McGraw Hill Professional this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-11 with Business & Economics categories.
The definitive guide for navigating today’s credit agreements Today’s syndicated loan market and underlying credit agreements are far more complex than ever. Since the global financial crisis, the art of corporate loan syndications, loan trading, and investing in this asset class have changed dramatically. Lenders are more diverse, borrowers more demanding, and regulations more stringent. Consequently, the credit agreement has evolved, incorporating many new provisions and a host of revisions to existing ones. The LSTA’s Complete Credit Agreement Guide brings you up to speed on today’s credit agreements and helps you navigate these complex instruments. This comprehensive guide has been fully updated to address seven years of major change—which has all but transformed the loan market as we knew it. It provides everything you need to address these new developments, including what to look for in large sponsor-driven deals, the rise of “covenant lite” agreements for corporate borrowers seeking fewer covenant restrictions, Yankee Loans, other products resulting from globalization, and other product developments driven by the diversification of the investor class. You’ll benefit from the authors’ in-depth coverage of all the nuances of today's credit agreements, as well as their tips on how to protect your loan, manage defaults, and navigate cross-border deals. This reliable guide covers: o Commitments, Loans, and Letters of Credit o Interest and Fees o Amortization and Maturity o Conditions Precedent o Representations o Covenants o Guarantees and Security o Defaults and Enforcement o Interlender, Voting, and Agency issues o Defaulting Lenders o Assignments, Participations, and Disqualified Lender ListsBorrower Rights o Regulatory Developments Structuring and managing credit agreements has always been a difficult process – but now it’s more complicated than ever. Whether you work for a company that borrows money in the syndicated loan market or for a bank, a hedge fund, pension fund, insurance company, or other financial institution, the LSTA’s Complete Credit Agreement Guide puts you ahead of the curve of today’s credit landscape.
Musicmaster
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Author : Paul C. Mawhinney
language : en
Publisher:
Release Date : 1994
Musicmaster written by Paul C. Mawhinney and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Music categories.